Skip to main content

Table 3 Adjusted ROX index 6 h after HFNC onset according other risk factors of intubation in all cohorts (multivariate analysis)

From: Performance of the ROX index to predict intubation in immunocompromised patients receiving high-flow nasal cannula for acute respiratory failure


OR (95% CI)


Oxygen flow at randomization > 9 L/min

1.10 (0.64–1.88)



1.03 (0.58–1.83)


ARF related to pneumonia

1.06 (0.63–1.76)


SOFA Day 1 (per point increase)

1.17 (1.08–1.27)


ROX H6 (per point increase)

0.89 (0.82–0.96)


  1. Oxygen flow at ICU admission was dichotomized below or over 9 l/min
  2. Patients form IVNICTUS study were compared to patients from HIGH study
  3. ARF aetiology was dichotomized between ARF related to bacterial or viral pneumonia versus all other reason of ARF
  4. SOFA Day 1 was sequential organ failure assessment
  5. ROX index was used as continuous variable
  6. Characteristics of the multivariate model
  7. Hosmer and Lemeshow goodness of fit test p = 0.65
  8. The AUC of the ROC curve of the predictive model = 0.66
  9. The relationship between ROX index and lod(odds) of intubation was linear
  10. ARF acute respiratory failure, NIV non-invasive ventilation, OR odds ratio, CI confidence interval