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Table 3 Comparison in safety between RCA and heparin anticoagulation for IHD

From: Comparison between regional citrate anticoagulation and heparin for intermittent hemodialysis in ICU patients: a propensity score-matched cohort study

Variables Before inverse probability of treatment weighting After inverse probability of treatment weighting
IHD sessions with RCA (n = 124) IHD sessions with heparin (n = 84) p-value IHD sessions with RCA (n = 112) IHD sessions with heparin (n = 82) p-value |d|
Calcium gluconate infusion for hypocalcemia during session, n (%) 10 (8.1) 1 (1.2) 0.008 (6.9) (2.1) 0.22 0.235
Hemorrhagic events, n (%)       0.15  
 Type I 0 (0) 0 (0) 1 0 (0) 0 (0)   NA
 Type II 2 (1.6) 0 (0) 0.52 (2.7) (0)   0.235
 Type III 5 (4) 7 (8.3) 0.21 (3.8) (8.9)   0.211
Interventions for hemodynamic instability, n(%)
 Ultrafiltration stopping 12 (9.7) 16 (19.1) 0.11 (9.0) (17.8) 0.09 0.261
 Fluid bolus 5 (4) 6 (7.1) 0.33 (3.7) (7.1) 0.29 0.151
 Increasing dose of vasopressor amine 22 (17.7) 19 (22.6) 0.08 (14.7) (20.6) 0.29 0.155
Causes of premature termination of session, n (%)
 Hemodynamic instability 6 (4.8) 6 (7.1) 0.49 (4.4) (9.1) 0.22 0.188
 Catheter dysfunction 7 (5.6) 7 (8.3) 0.37 (5.5) (11.4) 0.16 0.213
 Acute high transmembrane pressure 26 (21) 6 (7) 0.02 (20.2) (8.8) 0.03 0.327
 Circuit clotting 16 (12.9) 2 (2.4) 0.02 (12.2) (2.9) 0.02 0.355
  1. NA, not applicable, RCA, regional citrate anticoagulation, IHD intermittent hemodialysis