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Table 3 Comparison in safety between RCA and heparin anticoagulation for IHD

From: Comparison between regional citrate anticoagulation and heparin for intermittent hemodialysis in ICU patients: a propensity score-matched cohort study

Variables

Before inverse probability of treatment weighting

After inverse probability of treatment weighting

IHD sessions with RCA (n = 124)

IHD sessions with heparin (n = 84)

p-value

IHD sessions with RCA (n = 112)

IHD sessions with heparin (n = 82)

p-value

|d|

Calcium gluconate infusion for hypocalcemia during session, n (%)

10 (8.1)

1 (1.2)

0.008

(6.9)

(2.1)

0.22

0.235

Hemorrhagic events, n (%)

     

0.15

 

 Type I

0 (0)

0 (0)

1

0 (0)

0 (0)

 

NA

 Type II

2 (1.6)

0 (0)

0.52

(2.7)

(0)

 

0.235

 Type III

5 (4)

7 (8.3)

0.21

(3.8)

(8.9)

 

0.211

Interventions for hemodynamic instability, n(%)

 Ultrafiltration stopping

12 (9.7)

16 (19.1)

0.11

(9.0)

(17.8)

0.09

0.261

 Fluid bolus

5 (4)

6 (7.1)

0.33

(3.7)

(7.1)

0.29

0.151

 Increasing dose of vasopressor amine

22 (17.7)

19 (22.6)

0.08

(14.7)

(20.6)

0.29

0.155

Causes of premature termination of session, n (%)

 Hemodynamic instability

6 (4.8)

6 (7.1)

0.49

(4.4)

(9.1)

0.22

0.188

 Catheter dysfunction

7 (5.6)

7 (8.3)

0.37

(5.5)

(11.4)

0.16

0.213

 Acute high transmembrane pressure

26 (21)

6 (7)

0.02

(20.2)

(8.8)

0.03

0.327

 Circuit clotting

16 (12.9)

2 (2.4)

0.02

(12.2)

(2.9)

0.02

0.355

  1. NA, not applicable, RCA, regional citrate anticoagulation, IHD intermittent hemodialysis