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Table 4 Determinants associated with in-hospital mortality using Cox cause-specific model

From: Determinants of hospital and one-year mortality among older patients admitted to intensive care units: results from the multicentric SENIOREA cohort

 

Univariate

Multivariate

HR

95% CI

p

HR

95% CI

p

Gender (reference: male)

0.76

0.5–1.14

0.178

Admission SOFA Score (per 1 pt increment)

1.12

1.06–1.18

 < 0.001

Admission SAPS2 Score (per 1 pt increment)

1.03

1.02–1.04

 < 0.001

1.02

1.00–1.03

0.044

Primary ICU diagnosis (reference septic shock)

 Non-septic shock

1.01

0.38–2.64

0.989

0.51

0.16–1.56

0.237

 Resuscitated cardiac arrest

2.71

1.57–4.68

 < 0.001

2.29

1.17–4.48

0.015

 Acute on chronic respiratory failure

0.58

0.26–1.30

0.187

0.95

0.36–2.53

0.921

 Acute respiratory failure

0.46

0.24–0.87

0.017

0.55

0.25–1.21

0.139

 Neurological disorder

0.96

0.51–1.83

0.912

1.14

0.49–2.64

0.758

 Post-surgery

0.25

0.06–1.04

0.057

0.34

0.07–1.57

0.168

 Other

0.56

0.23–1.36

0.200

0.75

0.26–2.12

0.582

Invasive mechanical ventilation

2.56

1.11–5.89

0.027

1.48

0.52–4.21

0.466

RRT requirement

1.52

1.00–2.31

0.051

1.53

0.86–2.71

0.147

Vasopressor requirement

1.34

0.87–2.08

0.188

1.07

0.60–1.90

0.814

CIRS for geriatrics (per 1 pt increment)

0.99

0.94–1.03

0.560

 CIRS for geriatrics < 8

0.76

0.52–1.12

0.171

Residential living (reference: chronic care facility)

      

 Supervised residence setting

0.25

0.05–1.11

0.068

0.15

0.03–0.84

0.030

 At home

0.25

0.08–0.82

0.021

0.17

0.05–0.62

0.007

IADL (per 1 pt increment)

0.99

0.84–1.17

0.905

 IADL ≥ 4

0.99

0.68–1.47

0.998

Katz-ADL (per 1 pt increment)

0.97

0.83–1.13

0.705

 Katz-ADL ≥ 5

0.88

0.54–1.42

0.598

History of fall (reference: no)

      

 Yes

1.05

0.71–1.56

0.789

 Unknown

0.83

0.11–6.0

0.855

Cognitive impairment

0.96

0.63–1.48

0.872

Perceived quality of life (unhappy, very unhappy)

1.85

1.20–2.87

0.006

1.95

1.12–3.41

0.018

Chronic pain (reference: no)

      

 Mild

1.08

0.62–1.89

0.781

 Moderate

1.31

0.79–2.18

0.295

 Severe

1.01

0.57–1.77

0.987

Presence of anxiety: yes

1.36

0.90–2.05

0.140

1.64

1.00–2.69

0.051

Presence of depressive symptoms

1.17

0.79–1.74

0.424

Mini-Zarit (per 1 pt increment)

1.03

0.91–1.17

0.641

  < 2

1.00

0.65–1.52

0.990

Frailty (reference: robust)

      

 Prefrail

1.69

1.01–2.82

0.045

1.59

0.90–2.80

0.112

 Frail

1.59

0.93–2.71

0.092

1.03

0.50–2.14

0.933

  1. ADL, Activity of daily living, CIRS for geriatrics, Cumulative Illness Rating Scale for Geriatrics, IADL, Instrumental Activity of Daily Living, ICU, intensive care unit, RRT, renal replacement therapy, SAPS, Simplified Acute Physiology Score, SOFA, Sequential Organ Failure Assessment
  2. CIRS for geriatrics under 8 is suggestive of few comorbidities