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Table 4 Determinants associated with in-hospital mortality using Cox cause-specific model

From: Determinants of hospital and one-year mortality among older patients admitted to intensive care units: results from the multicentric SENIOREA cohort

  Univariate Multivariate
HR 95% CI p HR 95% CI p
Gender (reference: male) 0.76 0.5–1.14 0.178
Admission SOFA Score (per 1 pt increment) 1.12 1.06–1.18  < 0.001
Admission SAPS2 Score (per 1 pt increment) 1.03 1.02–1.04  < 0.001 1.02 1.00–1.03 0.044
Primary ICU diagnosis (reference septic shock)
 Non-septic shock 1.01 0.38–2.64 0.989 0.51 0.16–1.56 0.237
 Resuscitated cardiac arrest 2.71 1.57–4.68  < 0.001 2.29 1.17–4.48 0.015
 Acute on chronic respiratory failure 0.58 0.26–1.30 0.187 0.95 0.36–2.53 0.921
 Acute respiratory failure 0.46 0.24–0.87 0.017 0.55 0.25–1.21 0.139
 Neurological disorder 0.96 0.51–1.83 0.912 1.14 0.49–2.64 0.758
 Post-surgery 0.25 0.06–1.04 0.057 0.34 0.07–1.57 0.168
 Other 0.56 0.23–1.36 0.200 0.75 0.26–2.12 0.582
Invasive mechanical ventilation 2.56 1.11–5.89 0.027 1.48 0.52–4.21 0.466
RRT requirement 1.52 1.00–2.31 0.051 1.53 0.86–2.71 0.147
Vasopressor requirement 1.34 0.87–2.08 0.188 1.07 0.60–1.90 0.814
CIRS for geriatrics (per 1 pt increment) 0.99 0.94–1.03 0.560
 CIRS for geriatrics < 8 0.76 0.52–1.12 0.171
Residential living (reference: chronic care facility)       
 Supervised residence setting 0.25 0.05–1.11 0.068 0.15 0.03–0.84 0.030
 At home 0.25 0.08–0.82 0.021 0.17 0.05–0.62 0.007
IADL (per 1 pt increment) 0.99 0.84–1.17 0.905
 IADL ≥ 4 0.99 0.68–1.47 0.998
Katz-ADL (per 1 pt increment) 0.97 0.83–1.13 0.705
 Katz-ADL ≥ 5 0.88 0.54–1.42 0.598
History of fall (reference: no)       
 Yes 1.05 0.71–1.56 0.789
 Unknown 0.83 0.11–6.0 0.855
Cognitive impairment 0.96 0.63–1.48 0.872
Perceived quality of life (unhappy, very unhappy) 1.85 1.20–2.87 0.006 1.95 1.12–3.41 0.018
Chronic pain (reference: no)       
 Mild 1.08 0.62–1.89 0.781
 Moderate 1.31 0.79–2.18 0.295
 Severe 1.01 0.57–1.77 0.987
Presence of anxiety: yes 1.36 0.90–2.05 0.140 1.64 1.00–2.69 0.051
Presence of depressive symptoms 1.17 0.79–1.74 0.424
Mini-Zarit (per 1 pt increment) 1.03 0.91–1.17 0.641
  < 2 1.00 0.65–1.52 0.990
Frailty (reference: robust)       
 Prefrail 1.69 1.01–2.82 0.045 1.59 0.90–2.80 0.112
 Frail 1.59 0.93–2.71 0.092 1.03 0.50–2.14 0.933
  1. ADL, Activity of daily living, CIRS for geriatrics, Cumulative Illness Rating Scale for Geriatrics, IADL, Instrumental Activity of Daily Living, ICU, intensive care unit, RRT, renal replacement therapy, SAPS, Simplified Acute Physiology Score, SOFA, Sequential Organ Failure Assessment
  2. CIRS for geriatrics under 8 is suggestive of few comorbidities