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Table 5 Determinants associated with one-year mortality among patients who survived to hospitalization using Cox cause-specific model

From: Determinants of hospital and one-year mortality among older patients admitted to intensive care units: results from the multicentric SENIOREA cohort

 

Univariate

Multivariate

HR

95% CI

p

HR

95% CI

p

Gender (reference: male)

0.82

0.56–1.19

0.292

Admission SOFA Score (per 1 pt increment)

1.00

0.95–1.06

0.895

Admission SAPS2 Score (per 1 pt increment)

1.02

1.0–1.03

0.009

1.01

1.00–1.03

0.129

Primary ICU diagnosis (reference septic shock)

 Non-septic shock

2.82

1.05–7.58

0.040

4.60

1.12–18.79

0.034

 Resuscitated cardiac arrest

2.18

0.84–5.66

0.108

5.82

1.63–20.83

0.007

 Acute on chronic respiratory failure

1.90

0.85–4.23

0.116

3.85

1.09–13.60

0.037

 Acute respiratory failure

1.40

0.67–2.92

0.377

3.46

1.08–11.14

0.037

 Acute kidney injury/metabolic disorders

1.89

0.51–7.00

0.338

4.99

1.00–24.93

0.050

 Neurological disorder

2.84

1.24–6.49

0.013

6.70

2.01–22.33

0.002

 Post-surgery

1.82

0.68–4.88

0.236

5.80

1.39–24.25

0.016

 Other

1.38

0.55–3.48

0.493

4.97

1.40–17.69

0.013

Invasive mechanical ventilation

1.23

0.79–1.92

0.351

Length of mechanical ≥ 3 days (reference < 3 days)

1.62

1.06–2.47

0.025

1.86

1.06–3.26

0.031

Length of RRT (reference no RRT)

  < 3 days

0.46

0.11–1.86

0.275

0.77

0.17–3.52

0.739

  ≥ 3 days

2.40

1.25–4.61

0.008

2.34

0.77–7.13

0.135

Length of vasopressor requirement (reference no vasopressor)

  < 3 days

0.89

0.56–1.43

0.640

  ≥ 3 days

1.26

0.78–2.03

0.352

CIRS for geriatrics (per 1 pt increment)

1.03

0.99–1.08

0.146

1.01

0.95–1.07

0.747

 CIRS for geriatrics < 8

1.20

0.82–1.77

0.344

Residential living (reference chronic care facility)

 Supervised residence setting

0.20

0.02–1.58

0.126

0.09

0.01–0.86

0.036

 At home

0.16

0.02–1.15

0.068

0.10

0.01–0.88

0.038

IADL (per 1 pt increment)

0.77

0.66–0.90

0.001

 IADL ≥ 4

0.52

0.34–0.79

0.002

0.75

0.41–1.36

0.339

Katz-ADL (per 1 pt increment)

0.78

0.69–0.89

 < 0.001

 Katz-ADL ≥ 5

0.41

0.28–0.61

 < 0.001

0.53

0.30–0.96

0.038

History of fall (reference: no)

 Yes

1.02

0.69–1.5

0.924

 Unknown

2.19

0.30–15.83

0.438

Cognitive impairment

1.14

0.76–1.72

0.526

Perceived quality of life (unhappy, very unhappy)

1.59

1.03–2.45

0.036

1.11

0.62–1.98

0.723

Chronic pain (reference: no)

 Mild

0.89

0.50–1.59

0.699

 Moderate

1.34

0.82–2.18

0.236

 Severe

1.10

0.63–1.92

0.733

Presence of anxiety

1.17

0.79–1.75

0.431

Presence of depressive symptoms

1.32

0.89–1.96

0.164

0.90

0.52–1.55

0.698

Mini-Zarit (per 1 pt increment)

1.24

1.09–1.41

0.001

  < 2

1.71

1.14–2.58

0.010

1.13

0.64–1.99

0.664

Frailty (reference: robust)

 Prefrail

1.28

0.74–2.22

0.377

0.96

0.50–1.85

0.903

 Frail

2.41

1.42–4.06

0.001

1.51

0.75–3.05

0.244

  1. ADL, activity of daily living, CIRS for geriatrics, Cumulative Illness Rating Scale for Geriatrics, IADL, Instrumental Activity of Daily Living, ICU, intensive care unit, RRT, renal replacement therapy, SAPS, Simplified Acute Physiology Score, SOFA, Sequential Organ Failure Assessment
  2. CIRS for geriatrics under 8 is suggestive of few comorbidities