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Table 5 Determinants associated with one-year mortality among patients who survived to hospitalization using Cox cause-specific model

From: Determinants of hospital and one-year mortality among older patients admitted to intensive care units: results from the multicentric SENIOREA cohort

  Univariate Multivariate
HR 95% CI p HR 95% CI p
Gender (reference: male) 0.82 0.56–1.19 0.292
Admission SOFA Score (per 1 pt increment) 1.00 0.95–1.06 0.895
Admission SAPS2 Score (per 1 pt increment) 1.02 1.0–1.03 0.009 1.01 1.00–1.03 0.129
Primary ICU diagnosis (reference septic shock)
 Non-septic shock 2.82 1.05–7.58 0.040 4.60 1.12–18.79 0.034
 Resuscitated cardiac arrest 2.18 0.84–5.66 0.108 5.82 1.63–20.83 0.007
 Acute on chronic respiratory failure 1.90 0.85–4.23 0.116 3.85 1.09–13.60 0.037
 Acute respiratory failure 1.40 0.67–2.92 0.377 3.46 1.08–11.14 0.037
 Acute kidney injury/metabolic disorders 1.89 0.51–7.00 0.338 4.99 1.00–24.93 0.050
 Neurological disorder 2.84 1.24–6.49 0.013 6.70 2.01–22.33 0.002
 Post-surgery 1.82 0.68–4.88 0.236 5.80 1.39–24.25 0.016
 Other 1.38 0.55–3.48 0.493 4.97 1.40–17.69 0.013
Invasive mechanical ventilation 1.23 0.79–1.92 0.351
Length of mechanical ≥ 3 days (reference < 3 days) 1.62 1.06–2.47 0.025 1.86 1.06–3.26 0.031
Length of RRT (reference no RRT)
  < 3 days 0.46 0.11–1.86 0.275 0.77 0.17–3.52 0.739
  ≥ 3 days 2.40 1.25–4.61 0.008 2.34 0.77–7.13 0.135
Length of vasopressor requirement (reference no vasopressor)
  < 3 days 0.89 0.56–1.43 0.640
  ≥ 3 days 1.26 0.78–2.03 0.352
CIRS for geriatrics (per 1 pt increment) 1.03 0.99–1.08 0.146 1.01 0.95–1.07 0.747
 CIRS for geriatrics < 8 1.20 0.82–1.77 0.344
Residential living (reference chronic care facility)
 Supervised residence setting 0.20 0.02–1.58 0.126 0.09 0.01–0.86 0.036
 At home 0.16 0.02–1.15 0.068 0.10 0.01–0.88 0.038
IADL (per 1 pt increment) 0.77 0.66–0.90 0.001
 IADL ≥ 4 0.52 0.34–0.79 0.002 0.75 0.41–1.36 0.339
Katz-ADL (per 1 pt increment) 0.78 0.69–0.89  < 0.001
 Katz-ADL ≥ 5 0.41 0.28–0.61  < 0.001 0.53 0.30–0.96 0.038
History of fall (reference: no)
 Yes 1.02 0.69–1.5 0.924
 Unknown 2.19 0.30–15.83 0.438
Cognitive impairment 1.14 0.76–1.72 0.526
Perceived quality of life (unhappy, very unhappy) 1.59 1.03–2.45 0.036 1.11 0.62–1.98 0.723
Chronic pain (reference: no)
 Mild 0.89 0.50–1.59 0.699
 Moderate 1.34 0.82–2.18 0.236
 Severe 1.10 0.63–1.92 0.733
Presence of anxiety 1.17 0.79–1.75 0.431
Presence of depressive symptoms 1.32 0.89–1.96 0.164 0.90 0.52–1.55 0.698
Mini-Zarit (per 1 pt increment) 1.24 1.09–1.41 0.001
  < 2 1.71 1.14–2.58 0.010 1.13 0.64–1.99 0.664
Frailty (reference: robust)
 Prefrail 1.28 0.74–2.22 0.377 0.96 0.50–1.85 0.903
 Frail 2.41 1.42–4.06 0.001 1.51 0.75–3.05 0.244
  1. ADL, activity of daily living, CIRS for geriatrics, Cumulative Illness Rating Scale for Geriatrics, IADL, Instrumental Activity of Daily Living, ICU, intensive care unit, RRT, renal replacement therapy, SAPS, Simplified Acute Physiology Score, SOFA, Sequential Organ Failure Assessment
  2. CIRS for geriatrics under 8 is suggestive of few comorbidities