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Table 1 Demographic summary of male and female cohorts

From: Insulin sensitivity in critically ill patients: are women more insulin resistant?

 

Males

Females

P-value

Demographic statistics

 # Patients

91 (63%)

54 (37%)

 

 Age

67 [57, 77]

67 [58, 74]

0.63a

 Mortality

18%

19%

1.0b

 APACHE II score

20 [16 27]

19.5 [17, 26]

0.98a

 First day SOFA score

6 [4 8]

5.5 [4, 8]

0.46a

 ICU length of stay (h)

108 [67.2, 188.4]

127.2 [64.8, 213.6]

0.91a

 SPRINT duration (h)

83 [45.5, 157.3]

86.5 [39, 167]

0.81a

 T2DM (%)

13 (14%)

11 (20%)

0.4b

Per-patient GC statistics

 Median BG (mmol/L)

5.7 [5.2, 6.1]

6.0 [5.3, 6.4]

0.06a

 Median % BG 4.4–8.0 mmol/L

83 [72, 90]

82 [67, 89]

0.3a

 Median % BG < 4.0 mmol/L

1.4 [0, 5.5]

1.4 [0, 6.9]

0.42a

 Median %BG < 2.2 mmol/L

0 [0, 0]

0 [0, 0]

1.0a

 BG measurements/day

15.8 [14.4, 17.5]

15.7 [14.5, 18.2]

0.47a

 Median insulin (U/h)

3 [2, 3]

3 [2, 3]

0.26a

 Median feed excl. hours not fed (g/h)

3.5 [2.1, 5.5]

2.8 [1.8, 3.9]

 < 0.01a

 Median feed excl. hours not fed (%GF)

51 [30, 80]

51 [30, 75]

0.61a

 GF (g/h)

6.5 [6.5, 7.4]

5.2 [5.2, 5.7]

 < 0.01a

Cohort statistics

 Cohort BG (mmol/L)

5.6 [4.9, 6.6]

5.9 [5.0, 6.9]

 < 0.01ac

 % BG 4.4–8.0 mmol/L

80.6

76.9

 < 0.01b

 % BG < 4.0 mmol/L

3.2

3.8

0.11b

 %BG < 2.2 mmol/L

0

0

1.0b

 Insulin (U/h)

3 [1 4]

3 [2 4]

 < 0.01a

 Hours not fed

1914 (35%)

861 (27%)

 < 0.01a

 Feed excl. hours not fed (g/h)

3.8 [2.0, 5.8]

2.4 [1.7 3.9]

 < 0.01a

 Feed excl. hours not fed (%GF)

55 [29 83]

47 [29 75]

 < 0.01a

  1. P-values are not adjusted for multiple comparisons. Median [IQR] is given where appropriate. T2DM = pre-diagnosed type 2 diabetes mellitus, GF = goal feed, and BG = blood glucose. BG is hourly resampled to allow fair comparison.
  2. Statistical difference is shown using (a) the Wilcoxon rank-sum test or (b) Fisher exact test where appropriate. (c) indicates clinical equivalence regardless of statistical significance, as further explained in the methods