TY - JOUR AU - Daubin, Cédric AU - Fournel, François AU - Thiollière, Fabrice AU - Daviaud, Fabrice AU - Ramakers, Michel AU - Polito, Andréa AU - Flocard, Bernard AU - Valette, Xavier AU - Du Cheyron, Damien AU - Terzi, Nicolas AU - Fartoukh, Muriel AU - Allouche, Stephane AU - Parienti, Jean-Jacques AU - from the PROCALCIVIR and BPCTrea study group PY - 2021 DA - 2021/03/06 TI - Ability of procalcitonin to distinguish between bacterial and nonbacterial infection in severe acute exacerbation of chronic obstructive pulmonary syndrome in the ICU JO - Annals of Intensive Care SP - 39 VL - 11 IS - 1 AB - To assess the ability of procalcitonin (PCT) to distinguish between bacterial and nonbacterial causes of patients with severe acute exacerbation of COPD (AECOPD) admitted to the ICU, we conducted a retrospective analysis of two prospective studies including 375 patients with severe AECOPD with suspected lower respiratory tract infections. PCT levels were sequentially assessed at the time of inclusion, 6 h after and at day 1, using a sensitive immunoassay. The patients were classified according to the presence of a documented bacterial infection (including bacterial and viral coinfection) (BAC + group), or the absence of a documented bacterial infection (i.e., a documented viral infection alone or absence of a documented pathogen) (BAC- group). The accuracy of PCT levels in predicting bacterial infection (BAC + group) vs no bacterial infection (BAC- group) at different time points was evaluated by receiver operating characteristic (ROC) analysis. SN - 2110-5820 UR - https://doi.org/10.1186/s13613-021-00816-6 DO - 10.1186/s13613-021-00816-6 ID - Daubin2021 ER -