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Table 1 General characteristics of selected studies

From: Predictors of fluid responsiveness in critically ill patients mechanically ventilated at low tidal volumes: systematic review and meta-analysis

# Study Year Setting Sample size Predictor to fluid responsiveness Method to measure cardiac output Infusion volume Tidal volume (ml/kg) PEEP (mmHg) Compliance (ml/cmH2O) ARDS (%)
1 De Backer [4] 2005 Sepsis 33 PPV TD (PAC) 500–100 ml LR and colloid 6.3 (6.0–7.1) 11.0 26.0 97.0
2 Auler et al.[26] 2008 Cardiovascular 59 PPV TD (PAC) 20 ml/kg LR 8.0 5.0 NR NR
3 Huang et al. [27] 2008 Sepsis 22 PPV TD (PAC) 500 ml colloid 6.4 (0.7) 14.4 26.2 100.0
4 Vistisen et al. [28] 2009 Cardiovascular 23 PPV C-TD (PAC) 500 ml colloid 6.9 (6.1–7.7) ABW 6.0 NR NR
5 Vallée et al. [29] 2009 Sepsis 42 PPV TPTD 6 ml/kg colloid 6.6 (6.2–7.3) IBW 6.0 27.0 47.00
6 Muller et al. [8] 2010 Sepsis 57 PPV TD (PAC) and TPTD 250–500 ml saline and colloid 6.0 (4.8–7.8) IBW 4.0 26.4 NR
7 Moretti et al. [30] 2010 Neurology 29 ΔIVC TPTD 7 ml/kg colloid 8.0 0.0 NR NR
8 Lakhal et al. [31] 2011 Sepsis 65 PPV TD (PAC) and TPTD 500 ml colloid 6.9 (5.9–7.8) PBW 8.5 40.4 100.0
9 Muller et al. [32] 2011 Sepsis 39 Mini-fluid challenge VTI (TTE) 500 ml colloid 6.6 (6.3–7.1) IBW 5.0 12.0 100.0
10 Monnet et al.[7] 2012 Sepsis 28 PPV, PLR, EEOT TPTD 500 ml saline 7.1 (6.3–7.9) PBW 7.0 23 89.0
11 Cecconi et al. [33] 2012 Postsurgical 31 PPV, SVV C-PCA 250 ml colloid 8.0 PBW 5.0 NR NR
12 Yazigi et al. [34] 2012 Cardiovascular 60 PPV TD (PAC) 7 ml/kg colloid 8.0 0 NR NR
13 Oliveira-Costa et al. [35] 2012 Sepsis 37 PPV TD (PAC) 500–1000 ml LR and colloid 6.5 (6.0–6.5) IBW 7.5 34.0 27.0
14 Drvar et al. [36] 2013 Sepsis 46 PPV, SVV C-PCA 500 ml colloid 7.0 5.0 NR NR
15 Freitas et al. [37] 2013 Sepsis 40 PPV TD (PAC) 7 ml/kg colloid 6.0 PWB 10.0 31.0 100.0
16 Trepte et al.[38] 2013 Postsurgical 72 PPV, SVV TPTD 300 ml colloid 8.0 5.0 NR NR
17 Guarracino et al. [39] 2014 Sepsis 50 PPV PRAM 7 ml/kg colloid 7.0 (6.0–8.0) 6.0 NR NR
18 Kang et al. [40] 2014 Cardiovascular 54 SVV TD (PAC) 240 ml colloid 6.0 IBW 0.0. or 5.0 or 10.0 NR NR
19 Ibarra-Estrada et al. [41] 2015 Sepsis 59 PPV, SVV, PLR TPTD 7 ml/kg saline 6.0 (6.0–6.3) PWB 6.0 NR 73.0
20 Angappan et al. [42] 2015 Sepsis 45 SVV NC -PCA 500 ml colloid 8.0 NR NR NR
21 Mallat et al. [43] 2015 Sepsis 49 Mini-fluid challenge TPTD 500 ml colloid 6.8 (6.4–7.3) IBW 8.0 13.8 48.0
22 Vistisen et al. [44] 2017 Cardiovascular 41 PPV C-TD 500 ml LR and colloid 6.7 (0.94) NR NR NR
23 Liu et al. [45] 2016 Sepsis 96 PPV TPTD 500 ml saline 7.0 (6.2–7.8) PBW NR 28 100.0
24 Cherpanath et al. [46] 2016 Cardiovascular 22 PPV, SVV NC -PCA 500 ml colloid 7.0 (6.0–8.0) ABW 5.0 NR NR
25 Oliveira et al. [47] 2016 Postsurgical 20 PPV, ΔIVC VTI (TTE) 500 ml LR 8.0 5.0 46.2 NR
26 Sobczyk et al. [48] 2016 Cardiovascular 35 PLR, ΔIVC VTI (TTE) 250 ml saline 8.0 5.0 NR NR
27 Myatra et al. [49] 2017 Sepsis 30 PPV, SVV, EEOT, tidal volume challenge TPTD 7 ml/kg saline 8.0 IBW 8.0 29.0 10.0
28 Yonis et al. [50] 2017 Sepsis 19 PPV, tidal volume challenge TPTD 500 ml LR 6.0 (5.9–6.1) PBW or 8.0 PBW 9.0 30.0 100.0
29 Jozwiak et al. [51] 2017 Sepsis 30 EEOT TPTD 500 ml saline 6.3 (5.8–6.5) PBW 10.0 12.0 20.0
30 Guo-Guang Ma et al. [52] 2018 Cardiovascular 70 SVV, PLR, ΔIVC NC -PCA 500 ml colloid 8.0 5.0 NR NR
31 Georges et al. [53] 2018 Neurology 50 EEOT VTI (TTE) 500 ml saline 6.9 (0.7) IBW 6.0 10.0 NR
32 Depret et at [54] 2019 Sepsis 28 EEOT TPTD 500 ml saline 5.8 (0.7) 11.0 11.0 71.0
33 Fot et al. [55] 2019 Cardiovascular 32 Mini-fluid challenge TPTD 7 ml/kg LR 7.6 (6.9–8.0) PBW 5.0 NR NR
  1. Values are expressed as pooled value (95% confidence interval). ABW, actual body weight; ARDS, acute respiratory distress syndrome; C-TD, continuous thermodilution; C-PCA, calibrated pulse contour analysis;; IBW, ideal body weight; PBW, predicted body weight; PEEP, positive end-expiratory pressure; EEOT, end expiratory occlusion test; NC-PCA, non-calibrated pulse contour analysis; NR, not reported; PPV, pulse pressure variation; SVV, stroke volume variation; LR, lactate ringer; PAC, pulmonary artery catheter; PLR, passive leg raising; PRAM, pressure recording analytical method; TD, thermodilution; TPTD, transpulmonary thermodilution; TTE, transthoracic echocardiography; VTI, velocity time integral; ΔIVC, inferior vena cava variability. Values are expressed as pooled data (95% confidence interval) or median (IQR)