Predictors of fluid responsiveness in critically ill patients mechanically ventilated at low tidal volumes: systematic review and meta-analysis

Alvarado Sánchez, Jorge Iván; Caicedo Ruiz, Juan Daniel; Diaztagle Fernández, Juan José; Amaya Zuñiga, William Fernando; Ospina-Tascón, Gustavo Adolfo; Cruz Martínez, Luis Eduardo

doi:10.1186/s13613-021-00817-5

Annals of Intensive Care

Table 1 General characteristics of selected studies

From: Predictors of fluid responsiveness in critically ill patients mechanically ventilated at low tidal volumes: systematic review and meta-analysis

#	Study	Year	Setting	Sample size	Predictor to fluid responsiveness	Method to measure cardiac output	Infusion volume	Tidal volume (ml/kg)	PEEP (mmHg)	Compliance (ml/cmH₂O)	ARDS (%)
1	De Backer [4]	2005	Sepsis	33	PPV	TD (PAC)	500–100 ml LR and colloid	6.3 (6.0–7.1)	11.0	26.0	97.0
2	Auler et al.[26]	2008	Cardiovascular	59	PPV	TD (PAC)	20 ml/kg LR	8.0	5.0	NR	NR
3	Huang et al. [27]	2008	Sepsis	22	PPV	TD (PAC)	500 ml colloid	6.4 (0.7)	14.4	26.2	100.0
4	Vistisen et al. [28]	2009	Cardiovascular	23	PPV	C-TD (PAC)	500 ml colloid	6.9 (6.1–7.7) ABW	6.0	NR	NR
5	Vallée et al. [29]	2009	Sepsis	42	PPV	TPTD	6 ml/kg colloid	6.6 (6.2–7.3) IBW	6.0	27.0	47.00
6	Muller et al. [8]	2010	Sepsis	57	PPV	TD (PAC) and TPTD	250–500 ml saline and colloid	6.0 (4.8–7.8) IBW	4.0	26.4	NR
7	Moretti et al. [30]	2010	Neurology	29	ΔIVC	TPTD	7 ml/kg colloid	8.0	0.0	NR	NR
8	Lakhal et al. [31]	2011	Sepsis	65	PPV	TD (PAC) and TPTD	500 ml colloid	6.9 (5.9–7.8) PBW	8.5	40.4	100.0
9	Muller et al. [32]	2011	Sepsis	39	Mini-fluid challenge	VTI (TTE)	500 ml colloid	6.6 (6.3–7.1) IBW	5.0	12.0	100.0
10	Monnet et al.[7]	2012	Sepsis	28	PPV, PLR, EEOT	TPTD	500 ml saline	7.1 (6.3–7.9) PBW	7.0	23	89.0
11	Cecconi et al. [33]	2012	Postsurgical	31	PPV, SVV	C-PCA	250 ml colloid	8.0 PBW	5.0	NR	NR
12	Yazigi et al. [34]	2012	Cardiovascular	60	PPV	TD (PAC)	7 ml/kg colloid	8.0	0	NR	NR
13	Oliveira-Costa et al. [35]	2012	Sepsis	37	PPV	TD (PAC)	500–1000 ml LR and colloid	6.5 (6.0–6.5) IBW	7.5	34.0	27.0
14	Drvar et al. [36]	2013	Sepsis	46	PPV, SVV	C-PCA	500 ml colloid	7.0	5.0	NR	NR
15	Freitas et al. [37]	2013	Sepsis	40	PPV	TD (PAC)	7 ml/kg colloid	6.0 PWB	10.0	31.0	100.0
16	Trepte et al.[38]	2013	Postsurgical	72	PPV, SVV	TPTD	300 ml colloid	8.0	5.0	NR	NR
17	Guarracino et al. [39]	2014	Sepsis	50	PPV	PRAM	7 ml/kg colloid	7.0 (6.0–8.0)	6.0	NR	NR
18	Kang et al. [40]	2014	Cardiovascular	54	SVV	TD (PAC)	240 ml colloid	6.0 IBW	0.0. or 5.0 or 10.0	NR	NR
19	Ibarra-Estrada et al. [41]	2015	Sepsis	59	PPV, SVV, PLR	TPTD	7 ml/kg saline	6.0 (6.0–6.3) PWB	6.0	NR	73.0
20	Angappan et al. [42]	2015	Sepsis	45	SVV	NC -PCA	500 ml colloid	8.0	NR	NR	NR
21	Mallat et al. [43]	2015	Sepsis	49	Mini-fluid challenge	TPTD	500 ml colloid	6.8 (6.4–7.3) IBW	8.0	13.8	48.0
22	Vistisen et al. [44]	2017	Cardiovascular	41	PPV	C-TD	500 ml LR and colloid	6.7 (0.94)	NR	NR	NR
23	Liu et al. [45]	2016	Sepsis	96	PPV	TPTD	500 ml saline	7.0 (6.2–7.8) PBW	NR	28	100.0
24	Cherpanath et al. [46]	2016	Cardiovascular	22	PPV, SVV	NC -PCA	500 ml colloid	7.0 (6.0–8.0) ABW	5.0	NR	NR
25	Oliveira et al. [47]	2016	Postsurgical	20	PPV, ΔIVC	VTI (TTE)	500 ml LR	8.0	5.0	46.2	NR
26	Sobczyk et al. [48]	2016	Cardiovascular	35	PLR, ΔIVC	VTI (TTE)	250 ml saline	8.0	5.0	NR	NR
27	Myatra et al. [49]	2017	Sepsis	30	PPV, SVV, EEOT, tidal volume challenge	TPTD	7 ml/kg saline	8.0 IBW	8.0	29.0	10.0
28	Yonis et al. [50]	2017	Sepsis	19	PPV, tidal volume challenge	TPTD	500 ml LR	6.0 (5.9–6.1) PBW or 8.0 PBW	9.0	30.0	100.0
29	Jozwiak et al. [51]	2017	Sepsis	30	EEOT	TPTD	500 ml saline	6.3 (5.8–6.5) PBW	10.0	12.0	20.0
30	Guo-Guang Ma et al. [52]	2018	Cardiovascular	70	SVV, PLR, ΔIVC	NC -PCA	500 ml colloid	8.0	5.0	NR	NR
31	Georges et al. [53]	2018	Neurology	50	EEOT	VTI (TTE)	500 ml saline	6.9 (0.7) IBW	6.0	10.0	NR
32	Depret et at [54]	2019	Sepsis	28	EEOT	TPTD	500 ml saline	5.8 (0.7)	11.0	11.0	71.0
33	Fot et al. [55]	2019	Cardiovascular	32	Mini-fluid challenge	TPTD	7 ml/kg LR	7.6 (6.9–8.0) PBW	5.0	NR	NR

Values are expressed as pooled value (95% confidence interval). ABW, actual body weight; ARDS, acute respiratory distress syndrome; C-TD, continuous thermodilution; C-PCA, calibrated pulse contour analysis;; IBW, ideal body weight; PBW, predicted body weight; PEEP, positive end-expiratory pressure; EEOT, end expiratory occlusion test; NC-PCA, non-calibrated pulse contour analysis; NR, not reported; PPV, pulse pressure variation; SVV, stroke volume variation; LR, lactate ringer; PAC, pulmonary artery catheter; PLR, passive leg raising; PRAM, pressure recording analytical method; TD, thermodilution; TPTD, transpulmonary thermodilution; TTE, transthoracic echocardiography; VTI, velocity time integral; ΔIVC, inferior vena cava variability. Values are expressed as pooled data (95% confidence interval) or median (IQR)

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