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Table 4 Subgroups and meta-regression analysis

From: Predictors of fluid responsiveness in critically ill patients mechanically ventilated at low tidal volumes: systematic review and meta-analysis

Subgroup Predictor of intravenous fluid Number of studies Odds ratio (95% CI) P value by meta-regression P value by subgroup analysis I2 (%) Q (value p)
Method to measure cardiac output
 TD PPV 6 22.64 (7.86–65.25) 0.001 0.02 43.86 28.50. p = 0.03
 TD and TDTP   2 17.58 (3.60–85.83) 0.79    
 TPTD   8 4.96 (2.20–11.17) 0.03    
 C-PCA   1 2173 (30.73–153,655.35) 0.04    
 TTE   1 130.33 (3.32–5114.78) 0.37    
 C-TD   2 11.57 (1.99–67.14) 0.52    
 Others   3 28.38 (6.67–141.94) 0.82    
 Others SVV 2 18.45 (3.73–91.24) 0.12  < 0.01 0.0 5.57. p = 0.47
 TPTD   3 7.02 (3.29–14.97)  < 0.01    
 C-PCA   1 697.00 (26.95–18,029) 0.23    
 TD   3 84.61 (29.50–242.72)  < 0.01    
 NC -PCA   2 64.49 (18.18–228.71) 0.75    
 Compliance PPV 13 DOR = 1.08 (IC 95% 1.00–1.16) 0.05 NA 47.90 21.11. p = 0.03
Threshold used
  > 7% SVV 3 86.54 (21.58–347.11) 0.02 0.05 39.17 13.15. p = 0.11
  > 10%   1 4.98 (0.77–32.15) 0.09    
  > 15%   7 33.10 (12.50–87-67) 0.08    
Critical care setting
 Sepsis SVV 4 21.23 (7.66–58.81)  < 0.01  < 0.01 15.33 9.45. p = 0.31
 Postsurgical   2 6.70 (2.25–19.98) 0.13    
 Cardiovascular   5 95.67 (36.77–250.54) 0.03    
Volume of fluid load
 250 ml SVV 4 54.10 (18.76–156.00)  < 0.01 0.01 21.79 8.95. p = 0.26
 300 ml   1 4.98 (1.14–21.82) 0.01    
 500 ml   4 86.73 (24.66–305.11) 0.57    
 7 ml/kg   2 11.82 (2.92–47.80) 0.09    
 250 ml PLR 1 17.10 (2.77–105.70)  < 0.01  < 0.01 0.0 0.01. p = 0.93
 500 ml   2 293.64 (33.14–2601.57) 0.05    
 7 ml/kg   1 4.84 (1.37–17.09) 0.26    
  1. C-PCA; calibrated pulse contour analysis; C-TD, continuous thermodilution; NC-PCA, non-calibrated pulse contour analysis; I2, inconsistency; PAC, pulmonary artery catheter; PPV, pulse pressure variation; PLR, passive leg raising; Q, Cochrane statistics; TD; thermodilution; TPTD, transpulmonary thermodilution; TTE; TTE, transthoracic echocardiography: SVV, stroke volume variability. Values are expressed as pooled data (95% confidence interval)