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Table 1 Characteristics of 90 SRD patients given ECMO support

From: Outcomes of severe systemic rheumatic disease patients requiring extracorporeal membrane oxygenation

Variables

Value

Women

60 (66.7)

Body mass index, kg/m2

26.3 ± 6.8

Age at ICU admission, years

41.6 ± 15.2

Systemic rheumatic diseases

 Diagnosis in the ICU

31 (34.4)

 Diagnosis-to-ICU interval*, months

93 (25–132)

 Connective tissue diseases

52 (57.8)

  Systemic lupus erythematosus

22 (24.4)

  Idiopathic inflammatory myositis

12 (13.3)

  Antiphospholipid syndrome

12 (13.3)

  Systemic sclerosis

5 (5.6)

  Mixed connective tissue disease

5 (5.6)

  Sjögren’s syndrome

3 (3.3)

  Rheumatic disorders

10 (11.1)

 Vasculitides

10 (11.1)

  Goodpasture’s syndrome

3 (3.3)

  ANCA-associated

5 (5.6)

  Small-vessel

1 (1.1)

  IgA-associated

1 (1.1)

 Sarcoidosis

5 (5.6)

 Nonmalignant eosinophilia-related diseases

4 (4.4)

 Adult-onset Still’s disease

4 (4.4)

 Others

5 (5.6)

Pre-ICU Specific treatment(s)

  Corticosteroids

43 (47.8)

  Immunosuppressant(s)§

33 (36.7)

Flare-related admission

69 (76.7)

Infection-related admission

21 (23.3)

  1. Continuous variables are expressed as mean ± standard deviation or median [interquartile range]; categorical variables are expressed as n (%)
  2. ICU intensive care unit, ANCA antineutrophil cytoplasm antibodies, ECMO extracorporeal membrane oxygenation, SRD systemic rheumatic disease
  3. *Three missing data
  4. One each: myasthenia gravis, neuromyelitis optica, multicentric Castleman’s disease, autoimmune thrombocytopenic purpura or inflammatory bowel disease
  5. §Methotrexate n = 15, azathioprine n = 13, mycophenolate mofetil n = 9, cyclophosphamide n = 8, rituximab n = 6, tumor necrosis factor-inhibitor n = 6, calcineurin inhibitors n = 5, tocilizumab n = 2