Table 3 Univariable and multivariable analyses of factors associated with in-hospital mortality for the 90 ECMO-treated SRD patients
From: Outcomes of severe systemic rheumatic disease patients requiring extracorporeal membrane oxygenation
Factor | Univariable analysis | multivariable analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Age ≥ 40 years | 1.4 | 0.8–2.5 | 0.3 | |||
Women | 1.5 | 0.8–2.9 | 0.2 | |||
Pre-admission SRD lung involvement | 0.5 | 0.3–0.9 | 0.04 | 0.8 | 0.4–1.6 | 0.6 |
Pre-admission SRD heart involvement | 1.7 | 0.9–3.2 | 0.08 | 2.9 | 1.5–5.8 | 0.001 |
Corticosteroids before admission | 1.7 | 0.9–3.1 | 0.07 | 1.8 | 0.9–3.3 | 0.052 |
Immunosuppressants before admission | 1.3 | 0.7–2.3 | 0.4 | |||
In-ICU SRD diagnosis | 1.0 | 0.6–1.9 | 0.9 | |||
Day-0 SAPS II ≥ 70 | 2.7 | 1.5–4.9 | 0.001 | 2.7 | 1.4–5.1 | 0.003 |
Day-0 SOFA score ≥ 16 | 2.8 | 1.6–5.1 | < 0.0001 | |||
Flare-related admission | 1.4 | 0.6–3.0 | 0.7 | |||
VA-ECMO | 1.3 | 0.7–2.4 | 0.3 | |||
In-ICU corticosteroids | 0.8 | 0.4–1.5 | 0.5 | |||
In-ICU immunosuppressant(s) | 1.0 | 0.5–1.8 | 0.9 | |||
Vasopressors | 5.3 | 0.7–38.6 | 0.1 | 2.7 | 0.3–21.0 | 0.3 |
Mechanical ventilation | 1.8 | 0.2–13.2 | 0.5 | |||
Renal replacement therapy | 2.2 | 1.2–4.0 | 0.01 | 0.6 | 0.2–1.4 | 0.2 |
ICU-acquired infection | 1.0 | 0.6–2.0 | 0.9 | |||
Highest in-ICU value | ||||||
Arterial lactate ≥ 7.5 mmol/L | 3.2 | 1.7–5.9 | < 0.0001 | 2.8 | 1.4–5.3 | 0.002 |
Bilirubin ≥ 125 µmol/L | 2.3 | 1.2–4.3 | 0.007 | 2.0 | 1.0–3.9 | 0.04 |
Lowest in-ICU value | ||||||
Platelet count < 50 G/L | 2.9 | 1.4–6.0 | 0.004 | 1.8 | 0.7–4.5 | 0.2 |