Skip to main content

Table 1 Baseline characteristics

From: Validation of the pediatric refractory septic shock definition: post hoc analysis of a controlled trial

  All patients (n = 60) No RSS (n = 25) RSS (n = 35) P value
Age (years) 5.5 (1.0–8.3) 7.0 (4.0–10.2) 1.75 (0.78–1.2) 0.015
Sex female (%) 30 (50%) 11 (44%) 19 (54.3) 0.601
PRISM III at admission 20 (13.5–28.7) 15 (10–18.5) 23 (20–30.5)  < 0.0001
PELOD at admission 32 (12–42) 12 (10.7–31.2) 33 (31–42)  < 0.0001
Community acquired infection 56 (93.3%) 25 (100%) 31 (88.6%) 0.133
Healthcare-associated infection 4 (6.7%) 0 4 (11.4%)
Systemic infection 26 (43.3%) 16 (64%) 10 (28.5%) 0.008
Pneumonia 14 (23.3%) 5 (20%) 9 (25.7%) 0.761
Use of mechanical ventilation 47 (78.3%) 15 (60%) 32 (91.4%) 0.005
Use of epinephrine as first line 29 (48.3%) 15 (60%) 14 (40%) 0.190
Use of dopamine as first line 31 (51.7%) 10 (40%) 21 (60%)
Use of dobutamine or milrinone 39 (65%) 11 (44%) 27 (77.1%) 0.014
Use of hydrocortisone 44 (73.3) 14 (56%) 30 (85.7%) 0.017
Use of RBCs transfusion 30 (50%) 18 (72%) 14 (40%) 0.019
Use of RRT 24 (40%) 2 (8%) 22 (62.9%)  < 0.0001
Severe ARDS 17 (28.3%) 3 (12%) 14 (40%) 0.022
Cardiac arrest 4 (6.7%) 0 4 (11.4%) 0.133
Maximal blood lactate (mmol/L) 4.3 (2.6, 6.8) 2.8 (2.4–3.8) 5.5 (3.8–8.9)  < 0.0001
Lactate increase 34 (56.7%) 7 (28%) 27 (79.4%)  < 0.0001
ScvO2 < 70% 52 (86.7%) 20 (80%) 32 (91.4%) 0.259
Myocardial dysfunction on cardiac ultrasound 35 (58.3%) 0 35 (100%)  < 0.0001
Delay from septic shock onset to death 3 (1.0–6.7) 1.5 (1.0–2.0) 3.0 (1.0–7.0) 0.327
Bedside septic shock score (bSSS) 4.0 (0–4.0) 0 (0–1) 4 (4–5)  < 0.0001
Computed septic shock score (cSSS) 20.4 (2.3–21.5) 2.4 (2.3–2.4) 21.4 (20.7–22.3)  < 0.0001
Number of days in PICU 5 (2.7–7.0) 5 (4–7) 3 (2–7) 0.246
PICU mortality 32 (53.3%) 2 (8%) 30 (85.7%)  < 0.0001
  1. Values are expressed as means (standard deviations) or median (interquartile range), as appropriate or number (percent)
  2. PRISM Pediatric Risk of Mortality, PELOD Pediatric Logistic Organ Dysfunction, RBC red blood cell, ARDS acute respiratory distress syndrome, RRT renal replacement therapy, ScvO2 central venous oxygen saturation, PICU pediatric intensive care unit, b-/c-SSS bedside-/computed-Septic Shock Score