Table 1 Baseline characteristics
All patients (n = 60) | No RSS (n = 25) | RSS (n = 35) | P value | |
|---|---|---|---|---|
Age (years) | 5.5 (1.0–8.3) | 7.0 (4.0–10.2) | 1.75 (0.78–1.2) | 0.015 |
Sex female (%) | 30 (50%) | 11 (44%) | 19 (54.3) | 0.601 |
PRISM III at admission | 20 (13.5–28.7) | 15 (10–18.5) | 23 (20–30.5) | < 0.0001 |
PELOD at admission | 32 (12–42) | 12 (10.7–31.2) | 33 (31–42) | < 0.0001 |
Community acquired infection | 56 (93.3%) | 25 (100%) | 31 (88.6%) | 0.133 |
Healthcare-associated infection | 4 (6.7%) | 0 | 4 (11.4%) | |
Systemic infection | 26 (43.3%) | 16 (64%) | 10 (28.5%) | 0.008 |
Pneumonia | 14 (23.3%) | 5 (20%) | 9 (25.7%) | 0.761 |
Use of mechanical ventilation | 47 (78.3%) | 15 (60%) | 32 (91.4%) | 0.005 |
Use of epinephrine as first line | 29 (48.3%) | 15 (60%) | 14 (40%) | 0.190 |
Use of dopamine as first line | 31 (51.7%) | 10 (40%) | 21 (60%) | |
Use of dobutamine or milrinone | 39 (65%) | 11 (44%) | 27 (77.1%) | 0.014 |
Use of hydrocortisone | 44 (73.3) | 14 (56%) | 30 (85.7%) | 0.017 |
Use of RBCs transfusion | 30 (50%) | 18 (72%) | 14 (40%) | 0.019 |
Use of RRT | 24 (40%) | 2 (8%) | 22 (62.9%) | < 0.0001 |
Severe ARDS | 17 (28.3%) | 3 (12%) | 14 (40%) | 0.022 |
Cardiac arrest | 4 (6.7%) | 0 | 4 (11.4%) | 0.133 |
Maximal blood lactate (mmol/L) | 4.3 (2.6, 6.8) | 2.8 (2.4–3.8) | 5.5 (3.8–8.9) | < 0.0001 |
Lactate increase | 34 (56.7%) | 7 (28%) | 27 (79.4%) | < 0.0001 |
ScvO2 < 70% | 52 (86.7%) | 20 (80%) | 32 (91.4%) | 0.259 |
Myocardial dysfunction on cardiac ultrasound | 35 (58.3%) | 0 | 35 (100%) | < 0.0001 |
Delay from septic shock onset to death | 3 (1.0–6.7) | 1.5 (1.0–2.0) | 3.0 (1.0–7.0) | 0.327 |
Bedside septic shock score (bSSS) | 4.0 (0–4.0) | 0 (0–1) | 4 (4–5) | < 0.0001 |
Computed septic shock score (cSSS) | 20.4 (2.3–21.5) | 2.4 (2.3–2.4) | 21.4 (20.7–22.3) | < 0.0001 |
Number of days in PICU | 5 (2.7–7.0) | 5 (4–7) | 3 (2–7) | 0.246 |
PICU mortality | 32 (53.3%) | 2 (8%) | 30 (85.7%) | < 0.0001 |