Serum melatonin concentration in critically ill patients randomized to sedation or non-sedation

Annals of Intensive Care

Table 2 Medication during the 4-day study period

	Day 1		p	Day 2		p	Day 3		p	Day 4		p
	SEDA	NON-SEDA	p	SEDA	NON-SEDA	p	SEDA	NON-SEDA	p	SEDA	NON-SEDA	p
Propofol mg/kg/day	12.59 31/41 (0;34.5)	0 13/38 (0;2.17)	< 0,001	1.77 25/41 (0;16.3)	0 11/38 (0;0)	0.023	0 7/38 (0;0.3)	0 8/35 (0.72)	NS	0 4/34 (0;0)	0 8/31 0;1.53)	NS
Midazolam mg/kg/day	0 9/41 (0;0.68)	0 6/38 (0;0)	NS	0.38 33/41 (0;0.8)	0 6/38 (0;0)	< 0.001	0.51 30/38 (0.03;1.17)	0 5/35 (0;0)	< 0.001	0.4 24/34 (0;0.91)	0 4/35 (0;0)	< 0.001
Morphine mg/kg/day	0.11 34/41 (0.04;0.2)	0.25 35/38 (0.1;0.37)	0.007	0.14 38/41 (0.09;0.29)	0.24 34/38 (0.07;0.45)	NS	0.13 34/38 (0.05;0.26)	0.15 30/35 (0.06;0.54)	NS	0.16 31/34 (0.07;0.42)	0.14 26/31 (0.05;0.28)	NS
Clonidine μg/kg/day	0 4/41 (0;0)	0 13/38 (0;2.06)	0.002	0 9/41 (0;0.93)	0 14/38 (0;2.62)	NS	0 9/38 (0;1.09)	0.69 17/35 (0;3.5)	0,02	0 9/34 (0;0.71)	2.21 18/31 (0;3.94)	0.01
Halo-peridole mg/kg/day	0 1/41 (0;0)	0 7/38 (0;0)	0.02	0 1/41 (0;0)	0 6/38 (0;0)	0.04	0 2/38 (0;0)	0 7/35 (0;0)	0,08	0 0/34 (0;0)	0 7/31 (0;0)	0.09
Olanzapin mg/kg/day	0 1/41 (0;0)	0 0/38 (0;0)	NS	0 1/41 (0;0)	0 2/38 0;0	NS	0 0/38 (0;0)	0 5/35 (0;0)	0,009	0 0/34 (0;0)	0 5/31 (0;0)	0.016
Corticosteroid mg/kg/day	0.2 28/41 (0;1.6)	0.36 24/38 (0;2.15)	NS	0.13 25/41 (0;0.67)	0.33 24/38 (0;1.66)	NS	0.11 22/38 (0;0.67)	0.26 19/35 (0;0.73)	NS	0 15/34 (0;0.21)	0 13/31 (0;0.41)	NS
Patients N	41	38		41	38		38	35		34	31

Data are presented in medians with Interquartile Range. Corticosteroids were administered as methylprednisolone, hydrocortisone and prednisolone and dosing was equalized. Actual number of patients receiving the medication along with total number of patients in the group at individual times has been presented. NS = p > 0.1. Patients N = Number of patients investigated at individual times