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Table 1 Baseline characteristics between the two groups

From: Early combination of albumin with crystalloids administration might be beneficial for the survival of septic patients: a retrospective analysis from MIMIC-IV database

Variables Total population
(n = 7517)
Crystalloids alone
(n = 6597)
Early combination
(n = 920)
P
Age (yr) 66.75 (16.24) 67.02 (16.62) 67.11 (14.05) 0.852
Female (%) 3651 (48.57) 3253 (49.31) 398 (43.26)  < 0.001
White (%) 5359 (64.82) 4252 (64.45) 646 (70.22)  < 0.001
Heartrate (bpm) 89.98 (16.99) 89.83 (16.99) 89.39 (17.04) 0.463
MAP (mmHg) 78.14 (10.50) 78.96 (10.78) 74.10 (8.01)  < 0.001
Respiratory rate (bpm) 20.39 (4.21) 20.54 (4.21) 19.36 (3.93)  < 0.001
Temperature (°C) 36.91 (0.66) 36.93 (0.66) 36.81 (0.65)  < 0.001
SpO2 (%) 96.80 (2.73) 96.72 (2.78) 97.21 (2.46)  < 0.001
Urine output (L) 1.59 (1.23) 1.64 (1.27) 1.42 (1.04)  < 0.001
SAPS II score 35.45 (13.54) 34.98 (13.51) 36.88 (13.97)  < 0.001
SOFA score 4.85 (2.98) 4.64 (2.93) 5.74 (2.92)  < 0.001
Lactate (mmol/l) 2.63 (2.15) 2.50 (2.09) 2.99 (2.21)  < 0.001
Weight (kgs) 81.29 (25.66) 80.42 (25.82) 85.11 (22.70)  < 0.001
Ventilation (%) 3552 (47.25) 2893 (43.85) 659 (71.63)  < 0.001
RRT (%) 450 (5.99) 397 (6.02) 53 (5.76) 0.758
Vasopressor (%) 4119 (54.80) 3333 (50.52) 786 (85.43)  < 0.001
Admission, emergency (%) 4753 (63.23) 4363 (66.14) 390 (42.39)  < 0.001
Insurance (%) 3691 (50.73) 3269 (51.09) 422 (48.06) 0.050
AKI stage (%)      < 0.001
 3 2408 (32.03) 2002 (30.35) 406 (44.13)  
 2 2472 (32.89) 2127 (32.24) 345 (37.50)  
 1 1008 (13.41) 902 (13.67) 106 (11.52)  
 0 1629 (21.67) 1566 (23.74) 63 (6.85)  
Infection site, blood (%) 2330 (31.00) 2132 (32.32) 198 (21.52)  < 0.001
Septic shock (%) 2052 (27.30) 1828 (27.71) 224 (24.35) 0.032
Cancer (%) 1022 (13.60) 928 (14.07) 94 (10.22) 0.001
Renal disease (%) 1614 (21.47) 1426 (21.62) 188 (20.43) 0.414
Diabetes (%) 2250 (29.93) 1976 (29.95) 274 (29.78) 0.916
MI (%) 1139 (15.15) 964 (14.61) 175 (19.02)  < 0.001
Cirrhosis (%) 580 (7.72) 479 (7.26) 101 (10.98)  < 0.001
Antibiotic     
Carbapenems (%) 1095 (16.53) 938 (16.07) 157 (19.90) 0.007
Glycopeptide (%) 5785 (87.31) 5030 (86.17) 755 (95.69)  < 0.001
β-lactams (%) 1875 (28.30) 1754 (30.05) 121 (15.34)  < 0.001
Aminoglycosides (%) 147 (2.22) 124 (2.12) 23 (2.92) 0.157
  1. MAP mean arterial blood pressure, SAPS II Simplified Acute Physiology Score II, SOFA sequential organ failure assessment, RRT renal replacement therapy, AKI acute kidney injury, MI myocardial infarction
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