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Annals of Intensive Care

Table 4 Multivariate analysis of clinical success for all AG considering targeted Cmax (maximal concentration) attainment

From: An international survey on aminoglycoside practices in critically ill patients: the AMINO III study

 

Clinical success

 

OR (95% CI)

P value

Medical admission

1.08 [0.67; 1.74]

0.74

Male

0.60 [0.32; 1.12]

0.11

Age (years)

1.00 [0.99; 1.02]

0.67

BMI (kg m−2)

1.01 [0.97; 1.04]

0.91

SOFA score

0.85 [0.79; 0.91]

 < 0.0001

Serum creatinine (µmoL L−1)

1.00 [0.99; 1.0]

0.52

Empirical treatment

0.71 [0.33; 1.53]

0.39

Bacteremia

0.87 [0.49; 1.55]

0.64

Cmax attainment

1.24 [0.79; 1.94]

0.35

  1. Italic values indicates P values <0.05
  2. OR were calculated with a GEE model assuming an exchangeable correlation structure. P values result of a Wald test. The regression was based on 360 patients. The targeted Cmax was defined as a serum level above 60 mg L−1 for amikacin and 20 mg L−1 for gentamicin and tobramycin
  3. OR: odds ratio; CI: confidence interval, BMI: body mass index, GEE: generalized estimating equations
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