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Annals of Intensive Care

Table 5 Multivariate analysis of ICU mortality for all AG considering targeted Cmax (maximal concentration) attainment

From: An international survey on aminoglycoside practices in critically ill patients: the AMINO III study

 

ICU mortality

 

OR (95% CI)

P value

Medical admission

1.28 [0.75; 2.17]

0.36

Male

1.08 [0.73; 1.60]

0.69

Age (years)

1.03 [1.01; 1.04]

0.001

BMI (kg m−2)

1.00 [0.97; 1.04]

0.8

SOFA score

1.18 [1.10; 1.26]

 < 0.0001

Serum creatinine (µmoL L−1)

0.99 [0.99; 1.01]

0.32

Empirical treatment

0.81 [0.45; 1.48]

0.5

Bacteremia

0.62 [0.31; 1.25]

0.18

Cmax attainment

0.78 [0.46; 1.31]

0.34

  1. Italic values indicates P values <0.05
  2. OR were calculated with a GEE model assuming an exchangeable correlation structure. P values result of a Wald test. The regression was based on 393 patients. The targeted Cmax was defined as a serum level above 60 mg L−1 for amikacin and 20 mg L−1 for gentamicin and tobramycin
  3. OR: odds ratio, CI: confidence interval, BMI: body mass index, GEE: generalized estimating equations
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