Table 1 Baseline characteristics of the study population
Variables | All (n = 72) | No liver dysfunction (n = 50) | Severe liver dysfunction (n = 22) | p-value |
|---|---|---|---|---|
Age (years) | 63 (54–73) | 64 (55–73) | 62 (51–73) | 0.937 |
Males | 51 (71) | 34 (68) | 17 (77) | 0.308 |
BMI (kg/m2) | 27.3 (24.8–31.7) | 27.3 (24.9–30.8) | 27.3 (24.3–33.1) | 0.921 |
COVID-19 characteristics | ||||
Symptoms to ICU (days) | 6.9 (2–13.8) | 6.7 (2.4–14.2) | 6.5 (1.6–11.4) | 0.476 |
Symptoms—before ICU | ||||
Cough | 29 (40) | 20 (40) | 9 (41) | 0.783 |
Productive cough | 8 (11) | 4 (8) | 4 (18) | 0.214 |
Fever | 34 (47) | 23 (46) | 11 (50) | 0.581 |
Shortness of breath | 35 (49) | 26 (52) | 9 (41) | 0.579 |
Fatigue | 15 (21) | 10 (20) | 5 (23) | 0.748 |
Comorbidities | ||||
Charlson comorb. index, pts | 2 (1–3) | 2 (1–3) | 2 (1–3) | 0.480 |
Arterial hypertension (n, %) | 35 (49) | 26 (52) | 9 (41) | 0.245 |
Pre-existing medication | ||||
ACE inhibitor | 15 (21) | 12 (24) | 3 (14) | 0.255 |
Angiotensin receptor blocker | 8 (11) | 4 (8) | 4 (18) | 0.189 |
Chronic kidney disease | 8 (11) | 6 (12) | 2 (9) | 0.524 |
Coronary heart disease | 8 (11) | 6 (12) | 2 (9) | 0.524 |
Congestive heart failure | 2 (3) | 1 (2) | 1 (5) | 0.527 |
Diabetes mellitus | 23 (32) | 18 (36) | 5 (23) | 0.161 |
Chronic lung disease | 10 (14) | 8 (16) | 2 (9) | 0.341 |
Vital functions—admission | ||||
Body temperature (C°) | 37.3 (36.6–38.1) | 37.4 (36.7–38.1) | 37.3 (36.5–37.8) | 0.482 |
Heart rate (beats/minute) | 92 (81–108) | 91 (81–108) | 96 (80–107) | 0.531 |
Mean arterial pressure (mmHg) | 83 (72–100) | 82 (74–103) | 84 (71–90) | 0.337 |
Vasopressor use | 28 (39) | 20 (40) | 8 (36) | 0.466 |
Respiratory support—admission | ||||
paO2/FiO2 | 112 (84–168) | 107 (83–168) | 121 (102–160) | 0.570 |
Invasive mechanical ventilation | 25 (35) | 19 (38) | 6 (27) | 0.271 |
Non-invasive ventilation | 0 (0) | 0 (0) | 0 (0) | - |
High-flow nasal cannula | 9 (13) | 4 (8) | 5 (23) | 0.091 |
Laboratory results—admission | ||||
AST (U/l) | 48 (30–75.8) | 43 (29–70) | 56 (42–78) | 0.035 |
ALT (U/l) | 34 (22–59) | 31 (22–57) | 44 (44–76) | 0.271 |
Bilirubin (mg/dl) | 0.6 (0.4–0.8) | 0.5 (0.4–0.7) | 0.8 (0.5–1.4) | 0.002 |
Outcome | ||||
Duration ICU stay (days) | 13 (8.2–24.1) | 12.4 (5.9–21.6) | 16.8 (11.3–25.2) | 0.285 |
Died in ICU | 23 (32) | 8 (16) | 15 (68) | < 0.001 |