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Table 3 Multivariable logistic regression for factors associated with occurrence of severe liver dysfunction

From: Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?

Logistic regression Covariables OR (95% CI) p value
Step 1 Agea 0.986 (0.938–1.038) 0.614
SAPS II 1.073 (0.993–1.160) 0.073
Septic shock (yes vs. no) 2.139 (0.490–9.338) 0.311
ARDS (yes vs. no) 2.499 (0.932–6.701) 0.055
Viremiab (yes vs. no) 5,778 (1.160–28.769) 0.032
Step 2 SAPS II 1.066 (0.993–1.146) 0.083
Septic shock (yes vs. no) 2.313 (0.545–9.803) 0.255
ARDS (yes vs. no) 1.979 (0.672–3.865) 0.097
Viremia (yes vs. no) 5.581 (1.133–27.491) 0.034
Final model SAPS II 1.078 (1.004–1.157) 0.036
ARDS (yes vs. no) 1.764 (0.938–1.925) 0.118
Viremia (yes vs. no) 6.359 (1.336–30.253) 0.020
  1. OR odds ratio, CI confidence interval, ARDS acute respiratory distress syndrome, SAPS II Simplified Acute Physiology Score II
  2. aAge on admission was transformed prior to logistic regression analysis (natural logarithm)
  3. bViremia was defined as detectable viral RNA in blood quantified > 1000 copies/ml