Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?

Annals of Intensive Care

Table 3 Multivariable logistic regression for factors associated with occurrence of severe liver dysfunction

Logistic regression	Covariables	OR (95% CI)	p value
Step 1	Age^a	0.986 (0.938–1.038)	0.614
	SAPS II	1.073 (0.993–1.160)	0.073
	Septic shock (yes vs. no)	2.139 (0.490–9.338)	0.311
	ARDS (yes vs. no)	2.499 (0.932–6.701)	0.055
	Viremia^b (yes vs. no)	5,778 (1.160–28.769)	0.032
Step 2	SAPS II	1.066 (0.993–1.146)	0.083
	Septic shock (yes vs. no)	2.313 (0.545–9.803)	0.255
	ARDS (yes vs. no)	1.979 (0.672–3.865)	0.097
	Viremia (yes vs. no)	5.581 (1.133–27.491)	0.034
Final model	SAPS II	1.078 (1.004–1.157)	0.036
	ARDS (yes vs. no)	1.764 (0.938–1.925)	0.118
	Viremia (yes vs. no)	6.359 (1.336–30.253)	0.020

OR odds ratio, CI confidence interval, ARDS acute respiratory distress syndrome, SAPS II Simplified Acute Physiology Score II
^aAge on admission was transformed prior to logistic regression analysis (natural logarithm)
^bViremia was defined as detectable viral RNA in blood quantified > 1000 copies/ml