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Annals of Intensive Care

Table 2 Odds ratio of HFNO/MV in univariate binary logistic regression analysis

From: Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COVID-19 disease severity and indicator of the need for mechanical ventilation, ARDS and mortality

 

OR (95%CI), p value

Nagelkerke R Square

N/164

Gender

4.746 (1.833–12.286), = 0.001

.117

164

Age

1.077 (1.040–1.115), < 0.001

.206

164

BMI

1.012 (0.991–1.034), 0.272

.026

152

A.Hypertension

5.111 (2.182–11.974), < 0.001

.146

164

CAD

14.545 (4.190–50.497), < 0.001

.184

164

Diabetes Mellitus

2.600 (0.992–6.817), = 0.052

.034

164

Hyperlipidemia

2.568 (1.111–5.935), = 0.027

.045

164

Atherosclerosis

15.756 (5.623–44.149), < 0.001

.269

164

Renal insufficiency

7.000 (2.228–21.997), = 0.001

.102

164

COPD

3.629 (0.916–14.380), 0.067

.030

164

Inflammatory disease

0.373 (0.083–1.687), = 0.200

.020

164

Malignancy

1.253 (0.425–3.695), = 0.683

.013

164

ACE-I

5.057 (2.046–12.502), < 0.001

.111

164

ARB

1.673(0.597–4.687), 0.327

.009

164

Cortisone

4.121 (1.280–13.270), 0.018

.050

164

Statins

2.769 (1.165–6.581), 0.021

.048

164

ASS/Clopidogrel

3.582 (1.371–9.355), 0.009

.060

164

Horowitz index

0.975 (0.964–0.985), < 0.001

.747

87

SOFA

13.947 (4.162–46.736), < 0.001

.855

164

Maximum SOFA

27.437 (3.411–220.674), = 0.002

.934

164

qSOFA

13.217 (5.508–31.715), < 0.001

.340

164

Lactate

1.238 (1.096–1.399), = 0.001

.351

81

sRAGE Ln

9.509 (4.343–20.819), < 0.001

.472

164

Creatinine

10.894 (2.685–44.202), = 0.001

.306

163

Blood urea nitrogen

1.077 (1.038–1.116), < 0.001

.347

162

Troponin-T

1.201 (1.099–1.312), < 0.001

.569

100

Lactate dehydrogenase

1.009 (1.005–1.012), < 0.001

.369

162

AST

1.013 (1.004–1.022), = 0.005

.188

94

Bilirubin

6.996 (1.573–31.116), = 0.011

.180

89

Iron

0.708 (0.582–0.861), = 0.001

.241

157

Transferrin

0.015 (0.003–0.072), < 0.001

.435

157

Transferrin saturation

0.941 (0.893–0.991), = 0.021

.071

157

Ferritin

1.001 (1.000–1.001), = 0.002

.151

157

CRP

1.034 (1.023–1.046), < 0.001

.657

163

Leucocytes

1.458 (1.236–1.719), < 0.001

.248

164

Haemoglobin

0.676 (0.549–0.831), < 0.001

.148

164

Neutrophils

1.629 (1.342–1.978), < 0.001

.362

164

Lymphocytes

0.029 (0.007–0.129), < 0.001

.345

164

D-Dimer

2.548 (1.542–4.210), < 0.001

.407

112

NT-pro-BNP

1.001 (1.001–1.002), < 0.001

.451

143

CD25

1.002 (1.001–1.003), = 0.001

.330

69

IL-6

1.002 (1.000–1.005), 0.064

.091

84

  1. Table shows odds ratio (OR) of need for high-flow nasal oxygen therapy or mechanical ventilation, calculated using univariate binary logistic regression. Nagelkerke R square reflects the effect size of each variable. Not all variables were determined in outpatients, hence the number of patients analysed was noted (N/164). SOFA score, maximum SOFA score, Horowitz index, Troponin-T and sRAGE Ln have the largest effect size. BMI body mass index, A. Hypertension arterial hypertension, CAD coronary artery disease, COPD chronic obstructive pulmonary disease, ACE-I angiotensin converting enzyme inhibitor, ARB angiotensin II receptor blocker, SOFA sequential organ failure assessment score, qSOFA quick sequential organ failure assessment score, sRAGE Ln natural log transformed soluble receptor of advanced glycation end product, AST aspartate aminotransferase, CRP C-reactive protein, NT-pro-BNP N-terminal pro b-type Natriuretic Peptide, CD25 soluble interleukin (IL)-2Rα, IL-6 interleukin-6
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