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Table 3 Factors potentially associated with the choice of insertion site in univariate and multivariate analyses (between femoral and jugular for the first catheter, n = 439)

From: Vascular access for renal replacement therapy among 459 critically ill patients: a pragmatic analysis of the randomized AKIKI trial

Variablef

Femoral (n = 248)

Jugular (n = 191)

Univariate analysis

Multivariate analysis

p valuesa

OR (CI 95)

p valuesb

Randomization arm:delayed group

81 (32.7%)

68 (35.6%)

0.52

0.97 (0.59–1.58)

0.89

Age—years

64.51 (14.62)

66.21 (12.54)

0.44

  

Age > 70 years

103 (41.5%)

77 (40.3%)

0.80

1.08 (0.66–1.76)

0.78

Sex (Male)

174 (70.2%)

122 (63.9%)

0.16

1.43 (0.89—2.37)

0.16

Weight at randomization—mean (SD)

83.21 (19.9)

88.92 (25.2)

0.07

0.99 (0.98–0.99)

0.03

Peripheral vascular disease

35 (14.1%)

21 (11%)

0.33

1.46 (0.70–3.07)

0.32

ARDS at randomization

88/246 (35.8%)

61/190 (32.1%)

0.42

1.00 (0.59–1.68)

0.99

SAPS 3 score at randomization – mean (SD)

73.6 (15.5)

73.5 (12.5)

0.81

1.00 (0.98 – 1.01)

0.58

Invasive mechanical ventilation

211 (85.1%)

164 (85.9%)

0.82

0.85 (0.41 – 1.73)

0.38

Hemorrhagic risk c

172/225 (76.4%)

124/166 (74.7%)

0.69

1.01 (0.59 – 1.72)

0.98

Modality of first RRT Continuous

125 (50.6%)

75 (39.3%)

0.02

2.22 (1.28 – 3.86)

0.005

Investigator centerd

0.03e

  1. ap values: Pearson's Chi-squared for qualitative data and Wilcoxon rank sum test for quantitative data test.
  2. bp values: associated to multivariate logistic regression model.
  3. cHemorrhagic risk: ≥ one of the following criteria: platelets < 100 G/L, prothrombin ratio < 50%, anticoagulation therapy.
  4. dInvestigator center is a variable with 32 levels.
  5. ep value associated with investigator center: This center effect was evaluated by estimating the corresponding random effect variance component. The variance of center variable was of 0.38 (95% CI, 0.28–0.89). We also estimated the percentage of variance explained by the effect center and it was of 10.5%
  6. fCollinearity control: variance inflation factor (VIF) was lower than 1.5, thus judged adequate, for each fixed predictor (Additional file 3: Table S3).