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Table 1 Main clinical characteristics at admission or study inclusion

From: Monitoring skin blood flow to rapidly identify alterations in tissue perfusion during fluid removal using continuous veno-venous hemofiltration in patients with circulatory shock

Characteristic All patients (n =  42) Group A (n = 20) Group B (n = 22) p value
On admission
 Age (years) 63 (53–73) 68 (48–73) 61 (57–71) 0.6
 APACHE II score 24 (17–26) 22 (14–27) 24 (17–26) 0.8
 SOFA score 12 (9–14) 11 (8–14) 10 (10–14) 0.8
At study inclusion
 SOFA score 9 (8–12) 10 (9–12) 9 (7–10) 0.1
 Mean arterial pressure (mmHg) 77 (74–87) 78 (76–86) 76 (74–90) 0.3
 Heart rate (bpm) 97 (86–109) 99 (81–108) 97 (86–112) 0.5
 Cardiac index (L/min/m2) (n = 27) 3.1 (2.9–4.1) 3.1 (2.9–3.2) 3.0 (2.7–4.0) 0.6
 Norepinephrine dose (mcg/kg/min) (n = 34) 0.2 (0.1–0.5) 0.2 (0.2–0.5) 0.2 (0.1–0.6) 0.3
 Sedation, n (%) 19 (45%) 6 (30%) 13 (59%) 0.2
  Sufentanil (mcg/kg/h) 1.4 (1.3–1.6) 1.3 (1.3–1.4) 1.5 (1.2–1.8) 0.4
  Midazolam (mg/kg/h) 0.02 (0.01–0.03) 0.02 (0.01–0.02) 0.02 (0.02–0.03) 0.8
 PaO2/FiO2 197 (161–265) 172 (132–221) 198 (178–282) 0.1
 Central venous pressure (mmHg) 11 (8–14) 11 (8–13) 12 (7–15) 0.9
 Lactate concentration (mmol/l) 1.5 (1.2–2.1) 1.5 (1.2–2.1) 1.4 (1.2–2.1) 0.6
  Lactate concentration > 2 mmol/l, n (%) 11 (26) 5 (25) 6 (26) 0.7
 Oliguria (urine output < 0.5 ml/kg/h), n (%) 42 (100) 20 (100) 22 (100) 0.8
 ScvO2 (%) 71 (69–73) 71 (69–73) 70 (68–72) 0.8
 Capillary refill time (seconds) 2.2 (2.0–2.7) 2.2 (2.0–2.5) 2.4 (2.0–2.9) 0.4
 Hemoglobin level (g/dl) 9 (7–11) 10 (9–11) 9 (8–11) 0.3
 Peripheral perfusion index (PPI) 2 (0.8–2.3) 1.7 (1.4–2.1) 2.1 (0.8–2.3) 0.6
 Fluid removal rate (ml/h) 100 (100–200) 100 (100–200) 150 (100–200) 0.1
 Time between diagnosis of shock and start of fluid removal by CVVHDF (hours) 34 (24–49) 45 (36–50) 26 (14–48) 0.06
 Fluid removal duration (days) 10 (8–12) 8 (8–10) 10 (10–12) 0.1
 Cumulative fluid balance before start of fluid removal by CVVHDF (ml) 2404 (1368–3777) 3211 (2026–4000) 2235 (1368–3289) 0.2
 Mechanical ventilation, n (%) 22 (52) 7 (35) 15 (68) 0.03
  1. Data are expressed as median with 25th and 75th percentile unless otherwise specified
  2. APACHE II Acute Physiology and Chronic Health Evaluation II, CVVDHF continuous veno-venous hemodiafiltration, ScvO2 central venous oxygen saturation, SOFA Sequential Organ Failure Assessment