Table 1 Main clinical characteristics at admission or study inclusion
Characteristic | All patients (n = 42) | Group A (n = 20) | Group B (n = 22) | p value |
|---|---|---|---|---|
On admission | ||||
Age (years) | 63 (53–73) | 68 (48–73) | 61 (57–71) | 0.6 |
APACHE II score | 24 (17–26) | 22 (14–27) | 24 (17–26) | 0.8 |
SOFA score | 12 (9–14) | 11 (8–14) | 10 (10–14) | 0.8 |
At study inclusion | ||||
SOFA score | 9 (8–12) | 10 (9–12) | 9 (7–10) | 0.1 |
Mean arterial pressure (mmHg) | 77 (74–87) | 78 (76–86) | 76 (74–90) | 0.3 |
Heart rate (bpm) | 97 (86–109) | 99 (81–108) | 97 (86–112) | 0.5 |
Cardiac index (L/min/m2) (n = 27) | 3.1 (2.9–4.1) | 3.1 (2.9–3.2) | 3.0 (2.7–4.0) | 0.6 |
Norepinephrine dose (mcg/kg/min) (n = 34) | 0.2 (0.1–0.5) | 0.2 (0.2–0.5) | 0.2 (0.1–0.6) | 0.3 |
Sedation, n (%) | 19 (45%) | 6 (30%) | 13 (59%) | 0.2 |
Sufentanil (mcg/kg/h) | 1.4 (1.3–1.6) | 1.3 (1.3–1.4) | 1.5 (1.2–1.8) | 0.4 |
Midazolam (mg/kg/h) | 0.02 (0.01–0.03) | 0.02 (0.01–0.02) | 0.02 (0.02–0.03) | 0.8 |
PaO2/FiO2 | 197 (161–265) | 172 (132–221) | 198 (178–282) | 0.1 |
Central venous pressure (mmHg) | 11 (8–14) | 11 (8–13) | 12 (7–15) | 0.9 |
Lactate concentration (mmol/l) | 1.5 (1.2–2.1) | 1.5 (1.2–2.1) | 1.4 (1.2–2.1) | 0.6 |
Lactate concentration > 2 mmol/l, n (%) | 11 (26) | 5 (25) | 6 (26) | 0.7 |
Oliguria (urine output < 0.5 ml/kg/h), n (%) | 42 (100) | 20 (100) | 22 (100) | 0.8 |
ScvO2 (%) | 71 (69–73) | 71 (69–73) | 70 (68–72) | 0.8 |
Capillary refill time (seconds) | 2.2 (2.0–2.7) | 2.2 (2.0–2.5) | 2.4 (2.0–2.9) | 0.4 |
Hemoglobin level (g/dl) | 9 (7–11) | 10 (9–11) | 9 (8–11) | 0.3 |
Peripheral perfusion index (PPI) | 2 (0.8–2.3) | 1.7 (1.4–2.1) | 2.1 (0.8–2.3) | 0.6 |
Fluid removal rate (ml/h) | 100 (100–200) | 100 (100–200) | 150 (100–200) | 0.1 |
Time between diagnosis of shock and start of fluid removal by CVVHDF (hours) | 34 (24–49) | 45 (36–50) | 26 (14–48) | 0.06 |
Fluid removal duration (days) | 10 (8–12) | 8 (8–10) | 10 (10–12) | 0.1 |
Cumulative fluid balance before start of fluid removal by CVVHDF (ml) | 2404 (1368–3777) | 3211 (2026–4000) | 2235 (1368–3289) | 0.2 |
Mechanical ventilation, n (%) | 22 (52) | 7 (35) | 15 (68) | 0.03 |