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Table 2 Changes in systemic hemodynamic and microcirculatory parameters in septic patients before and after RIC during the study period

From: Effects of remote ischemic conditioning on microcirculatory alterations in patients with sepsis: a single-arm clinical trial

  I RIC at inclusion (n = 26) II RIC after 12 h (n = 23) III RIC after 24 h (n = 21)
Before After Before After Before After
MAP, mmHg 70 (62–78) 74 (66–80) 72 (69–80) 73 (70–82) 70 (64–76) 71 (65–79)
HR, beats/min 109 (84–121) 108 (86–127) 112 (81–126) 106 (85–122) 101 (77–115) 92 (81–121)
CI, L/min m2 3.7 (2.8–4.3) 3.9 (3.0–4.2) 3.9 (3.3–5.3) 4.2 (3.5–5.0) 4.1 (3.5–5.2) 4.1 (3.6–5.1)
Lactates, mmol/L 1.4 (1.2–3.0) 1.4 (1.1–4.4) 1.3 (1.2–1.7) 1.3 (1.1–2.0) 1.4 (1.0–2.1) 1.4 (0.9–2.5)
ScvO2, % 77.6 (74.0–82.1) 80.4 (71.9–83.3) 81.1 (73.8–85.1) 80.4 (72.3–84.7) 73.8 (70.8–82.0) 76.3 (69.3–81.8)
TVDs, mm/mm2 21.5 (19.1–25.1) 21.8 (18.7–24.4) 20 (17.8–25.8) 20.6 (19.1–24.5) 22.4 (18.8–24) 22.8 (20.5–25.3)
PVDs, mm/mm2 18.9 (16.8–21.6) 19.6 (17.1–21.8) 18.6 (16.5–23.7) 19.3 (17.5–21.0) 19.6 (16.6–22.2) 21.5 (18.6–22.4)
PPVs, % 87.9 (82.4–93.8) 92.5 (87.9–96.1)* 91.3 (84.6–95.8) 91.5 (86.4–95.4) 90.6 (85.2–94.3) 91.4 (86.5–95.8)
MFI 2.17 (1.81–2.69) 2.59 (2.21–2.83)* 2.5 (2.00–2.83) 2.58 (2.17–2.90) 2.33 (2.17–2.67) 2.50 (2.08–2.83)
DB, n/mm 12.7 (10.7–14.2) 12.2 (10.6–13.7) 12.1 (10.2–14.7) 11.6 (10.3–14) 12.6 (11.4–13.8) 12.8 (11.6–15.1)
  1. Data are presented as the median (interquartile range [IQR])
  2. MAP mean arterial pressure, HR heart rate, CI cardiac index, TVDs total vascular density of small vessels, PVDs perfused small vessel density, PPVs proportion of perfused small vessels, MFI microcirculatory flow index, DB De Backer score, ScvO2 central venous oxygen saturation
  3. *p < 0.05: significant difference before and after remote ischemic conditioning (RIC)