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Table 1 Classical and potential endpoint used to evaluate efficacy of AKI procedure

From: Outcome of acute kidney injury: how to make a difference?

  Classical outcome Potential outcome
Prevention AKI prevalence Real time GFR
  Change of biomarker  
Clinical management ICU death Time free of RRT
  Dialysis dependency at discharge AKI as competitive event to death/complicatoin
   Recovery of renal function
   Functional renal reserve
Follow-up Long-term survival Measure of GFR
  End-stage kidney disease Patient-related quality of life
  1. AKI acute kidney injury, GFR glomerular filtration rate, ICU intensive care unit, RRT renal replacement therapy, CKD chronic kidney disease