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Table 3 Acid–base parameters, hemofiltration settings, gas exchange and respiratory/ventilation parameters

From: Low bicarbonate replacement fluid normalizes metabolic alkalosis during continuous veno-venous hemofiltration with regional citrate anticoagulation

Parameter 0 h (at switch) 24 h (after switch) p
N = 42 N = 40
Acid–base parameters
 Bicarbonate, mmol/l 27.7 (26.9–28.9) 25.8 (24.6–27.7) 0.000*
 Base excess, mmol/l 4.0 (3.1–5.1) 1.8 (0.2–3.4) 0.000*
 pH 7.42 (7.38–7.47) 7.43 (7.37–7.46) 0.311
 Lactate, mg/dl 12.0 (7.3–14.0) 12.0 (8.0–15.0) 0.728
Haemofiltration settings
 Pre-dilution pre-blood pump fluid (Prismocitrate™), ml/h 1200 (1200–1300) 1,273 (1200–1300) 0.569
 Substitution rate, ml/h 800 (600–1000) 800 (500–1000) 0.943
 Fluid removal, ml/h 100 (100–188) 100 (100–150) 0.543
 Blood flow, ml/min 120 (125–130) 120 (120–130) 0.884
 Filtration fraction, % 33 (30–36) 33 (30–35) 0.799
 Temperature, °C 41.0 (40.0–43.0) 41.0 (39.8–43.0) 0.863
 Citrate dose, mmol/l 3.0 (3.0–3.2) 3.0 (3.0–3.2) 0.127
 Ionized serum calcium, mmol/l 1.09 (1.03–1.15) 1.06 (1.00–1.12) 0.170
 Calcium dose, mmol/h 2.45 (2.10–2.88) 2.65 (2.28–3.20) 0.196
 Calcium substitution, % 90 (85–105) 100 (88–111) 0.000*
 Post-filter calcium, mmol/l 0.41 (0.37–0.43) 0.37 (0.36–0.40) 0.006*
Gas exchange and respiratory/ventilation parameters
 PaCO2, mmHg 43.2 (39.7–47.5) 39.6 (36.8–46.1) 0.678
 PaO2, mmHg 82.9 (70.1–95.7) 84.2 (71.4–97.2) 0.691
 Peripheral arterial oxygen saturation, % 97.0 (93.7–98.3) 96.8 (95.5–98.3) 0.767
 PaO2/FiO2 ratio, mmHg 227 (131–298) 213 (136–328) 0.834
Ventilator parameters N = 25 N = 23  
 Respiratory rate, breaths/min 17 (14–20) 17 (15–20) 0.971
 FiO2 0.35 (0.30–0.50) 0.35 (0.30–0.53) 0.861
 Tidal volume, mL/kg PBWa 6.3 (5.8–6.9) 6.5 (5.9–7.8) 0.511
 Set positive end-expiratory pressure, cmH2O 8 (8–10) 8 (8–10) 0.733
 Peak pressure, cmH2O 19 (16–21) 18 (16–21) 0.529
 Driving pressure, cmH2O 10 (7–12) 9 (8–12) 0.510
 Minute ventilation, mL/kg PBWa/min 105 (85–123) 111 (85–135) 0.511
Non-invasive ventilation parameters N = 17 N = 17  
 FiO2 0.50 (0.23–0.68) 0.40 (0.21–0.49) 0.177
 Respiratory rate, breaths/min 16 (15–18) 20 (13–24) 0.404
  1. Data reported as median (IQR), unless otherwise specified
  2. aPBW predicted body weight