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Fig. 1 | Annals of Intensive Care

Fig. 1

From: Fluid-induced harm in the hospital: look beyond volume and start considering sodium. From physiology towards recommendations for daily practice in hospitalized adults

Fig. 1

Cumulative fluid balance of the MIHMoSA and TOPMAST trials. Both in healthy volunteers (MIHMoSA) and in patients undergoing major surgery (TOPMAST), fluid retention was significantly higher in the treatment arm receiving maintenance fluids containing 154 mmol/L of sodium (compared to 54 mmol/L). Compared to healthy subjects, the patient cohort had a more positive fluid balance, no matter the study fluid, partly due to other net fluid input (± 1.5 L) and partly due to the physiological response to hypovolemia, capillary leakage, etc. For details: see text. Adapted from Van Regenmortel et al. and Van Regenmortel et al., with permission [7, 8]

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