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Table 3 Weaning-induced pulmonary oedema according to adrenal reserve

From: Critical illness-related corticosteroid insufficiency during difficult weaning from mechanical ventilation

Variables WiPO classification
Conservative definition p value Liberal definition p value
Yes (n = 8) No (n = 68) Yes (n = 44) No (n = 32)
T0 (nmol/L) 833 (480–894) 637 (438–800) 0.18 675 (458–875) 611 (322–791) 0.17
T0 < 276 nmol/L 0 (0%) 9 (13.2%) 0.58 3 (6.8%) 6 (18.8%) 0.15
Tmax (nmol/L) 1136 (896–1439) 977 (781–1325) 0.47 1020 (896–1414) 893 (726–1322) 0.08
Δmax (nmol/L) 432 (201–519) 429 (267–614) 0.51 466 (279–610) 404 (222–574) 0.49
Δmax < 248 nmol/L 2 (25%) 15 (22.1%) > 0.99 9 (20.5%) 8 (25%) 0.64
AI (Huang and Lin def) 0 (0%) 10 (14.7%) 0.59 5 (11.4%) 5 (15.6%) 0.59
CIRCI 2 (25%) 23 (33.8%) > 0.99 12 (27.3%) 13 (40.6%) 0.22
  1. Values are expressed as mean (± SD) or median (IQR) as appropriate
  2. WiPO: weaning-induced pulmonary oedema, T0: baseline plasma cortisol (before short corticotropin test), Tmax: maximal cortisol post-stimulation, Δmax: maximal cortisol response, AI: adrenal insufficiency (Huang and Lin definition) = T0 < 25 μg/dL (694 nmol/L) and Δmax < 9 μg/dL (248 nmol/L), CIRCI: critical illness-related corticosteroid insufficiency = T0 < 10 μg/dL (276 nmol/L) and/or Δmax < 9 μg/dL (248 nmol/L)