Table 4 Specific treatment indications, performed interventions, compliance to Rowlands’ algorithm, severity factors, and outcome
From: Malignant pertussis in infants: factors associated with mortality in a multicenter cohort study
Indications according to [21]b | Performed interventions | Compliance to the algorithm | Factors contributing to severity | Outcome | ||
|---|---|---|---|---|---|---|
LD | ECLS | Yes/no | If no, criteria for deviation | |||
Urgent LD | 2 | 0 | Yes | PHT, KF, ARDS, seizures | Survivor | |
Urgent LD | 1 | 0 | No | > 24 h-delayed ECMO | Rapid worsening, ALF, KF, PHT, CPA | Non-survivor |
VA-ECMO + LD | 0 | VA-ECMO | No combined LD | Viral co-infection | ||
Urgent LD | 0 | 0 | No | No LD | ALF, KF, ARDS, PHT | Non-survivor |
VA-ECMO + LD | 0 | VV → VA-ECMO | > 24 h-delayed ECMO | Viral co-infection | ||
LD | 0 | 0 | No | No LD | Viral co-infection, PHT, ARDS | Non-survivor |
VA-ECMO + LD | 0 | VV → VA-ECMO | > 24 h-delayed ECMO, no combined LD | ECMO complication: limb ischemia | ||
Urgent LD | 1 | 0 | Yes | None | Survivor | |
LD | 1 | 0 | ||||
Urgent LD | 1 | 0 | Yes | Seizures | Survivor | |
LD | 1 | 0 | Yes | Bacterial superinfection, viral co-infection | Survivor | |
SIC | 0 | 0 | Yes | Viral co-infection | Survivor | |
VA-ECMO + LD | 1 | VA-ECMO | No | LD on time, but > 24 h-delayed ECMO + LDa | PHT, ARDS, KF, bacterial superinfections | Non-survivor |
ECMO complication: circuit thrombosis, extremities ischemia | ||||||
VA-ECMO | 0 | VA-ECMO | Yes | PHT, KF, bacterial superinfection | Survivor | |
SIC | 0 | 0 | Yes | None | Survivor | |
Urgent LD | 0 | 0 | No | No LD | ARDS, KF, CPA | Non-survivor |
VA-ECMO + LD | 0 | 0 | No ECMOa, no combined LD | |||
Urgent LD | 0 | 0 | No | No LD | PHT, seizures | Survivor |
Bacterial superinfection | ||||||
VA-ECMO + LD | 0 | 0 | No | No ECMOa, no combined LD | Rapid worsening, ARDS, PHT, KF, bacterial superinfection | Non-survivor |
LD | 1 | 0 | Yes | Bacterial superinfection, ARDS, HTP, KF | Survivor | |
Urgent LD | 0 | 0 | No | No LD | Viral co-infection, seizures | Survivor |
Urgent LD | 0 | 0 | No | > 24 h-delayed LD | HTP, KF, ALF, CPA, seizures, viral co-infection | Non-survivor |
VA-ECMO + LD | 0 | VA-ECMO | > 24 h-delayed ECMOa, no combined LD | ECMO complication: failure of ECMO procedure | ||
SIC | 0 | 0 | Yes | Bacterial superinfection, seizures, LTE | Survivor | |
SIC | 0 | 0 | Yes | None | Survivor | |
LD | 1 | 0 | Yes | None | Survivor | |
VA-ECMO + LD | 0 | 0 | No | No VA-ECMOa, no combined LD | Rapid worsening, ARDS, PHT, bacterial superinfection | Non-survivor |
Urgent LD | 1 | 0 | No | > 24 h-delayed LD | ARDS, CPA, PHT, KF, ALF, seizures | Non-survivor |
VA-ECMO + LD | 0 | VA-ECMO | > 24 h-delayed ECMOa, no combined LD | Bacterial superinfections | ||
Urgent LD | 1 | 0 | Yes | Bacterial superinfections, ARDS, seizures | Survivor | |