Table 1 Patients characteristics according to occurrence of AKI
From: Acute kidney injury in SARS-CoV2-related pneumonia ICU patients: a retrospective multicenter study
No AKI patients | AKI patients | P value | |
|---|---|---|---|
n | 184 | 195 | |
Age (years) | 60 [52–68] | 63 [54–69] | 0.03 |
Male gender | 129 (70.1%) | 162 (83.1%) | 0.004 |
Past medical history | |||
Chronic obstructive pulmonary disease | 5 (2.7%) | 15 (7.7%) | 0.05 |
Asthma | 13 (7.1%) | 10 (5.1%) | 0.57 |
Hypertension | 72 (39.1%) | 116 (59.5%) | < 0.001 |
Diabetes | 44 (23.9%) | 70 (35.9%) | 0.02 |
Immune defect | 27 (14.7%) | 41 (21.2%) | 0.13 |
Chronic heart failure | 8 (4.3%) | 24 (12.3%) | 0.009 |
Chronic kidney disease | 12 (6.5%) | 53 (27.2%) | < 0.001 |
Body mass index, kg/m2 | 29 [26–36] | 29 [26–32] | 0.14 |
Body weight class | 0.63 | ||
Overweight | 48 (28.9%) | 62 (32.6%) | |
Obese | 68 (41.0%) | 69 (36.3%) | |
Other | 50 (30.1%) | 59 (31.1%) | |
NSAIDs use before ICU | 5 (2.7%) | 6 (3.1%) | 1.000 |
Days since onset of disease | 0.02 | ||
1–7 days | 65 (35.5%) | 96 (49.7%) | |
8–14 days | 97 (53.0%) | 76 (39.4%) | |
> 14 days | 21 (11.5%) | 21 (10.9%) | |
Days between hospital and ICU admission | 1 [0–2] | 1 [0–3] | 0.26 |
Body Temperature (°C) | 37.6 [40.0–38.0] | 37.4 [36.3–38.3] | 0.63 |
Digestive tract symptoms | 51 (27.7%) | 48 (24.6%) | 0.57 |
Laboratory results at ICU admission | |||
Platelets (G/L) | 220 [167–284] | 199 [146–263] | 0.01 |
Creatinine (µmol/L) | 69 [61–83] | 107 [78–173] | < 0.001 |
C Reactive Protein | 159 [100–226] | 181 [106–268] | 0.05 |
Procalcitonin (µg/L) | 0.3 [0.2–0.6] | 0.8 [0.4–1.7] | < 0.001 |
LDH (UI/L) | 537 [454–751] | 593 [459–797] | 0.19 |
Fibrinogene (g/L) | 7.4 [6.3–7.5] | 7.2 [5.8–8.6] | 0.10 |
Ferritin | 1157 [687–2060] | 1554 [856–2749] | 0.09 |
Ddimeres | 1320 [753–2790] | 2244 [1025–4003] | 0.001 |
Organ support and dysfunction during first 24 h | |||
Oxygenation_modality (%) | < 0.001 | ||
Standard O2 | 49 (26.6%) | 19 (9.7%) | |
HFNO/NIV | 74 (40.2%) | 33 (16.9%) | |
Mechanical_ventilation | 61 (33.2%) | 143 (73.3%) | |
Normal Troponin | 136 (80.5%) | 70 (40.9%) | < 0.001 |
SOFA score | 3 [2–5] | 7 [4–9] | < 0.001 |
P/F ratio (mmHg) | 142 [86–191] | 124 [90–195] | 0.97 |
Vasopressors | 42 (22.8%) | 123 (63.1%) | < 0.001 |
Need for RRT during ICU stay | 10 (5.4%) | 64 (32.8%) | < 0.001 |
Worst KDIGO Stage at day 7 | < 0.001 | ||
No AKI | 184 (100%) | 0 (0.0) | |
Stage 1 | 0 | 58 (29.7%) | |
Stage 2 | 0 | 44 (22.6%) | |
Stage 3 | 0 | 93 (47.7%) | |
ICU mortality | 30 (18.8%) | 68 (42.5%) | < 0.001 |
Hospital Mortality | 30 (21.3%) | 73 (57.9%) | < 0.001 |
Day 28 mortality | 27 (14.7%) | 73 (37.4%) | < 0.001 |