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Table 2 Ventilatory management on the first 24 h after ICU admission, according to outcome at 28 days

From: Protective ventilation and outcomes of critically ill patients with COVID-19: a cohort study

Management All, n = 984 Survivors, n = 471 Nonsurvivors, n = 513 p value
Tidal volume (mL/Kg ideal body weight), mean (SD) 6.5 ± 1.3 6.5 ± 1.3 6.5 ± 1.3 0.82
Minute volume (L/min), mean (SD) 12.0 ± 3.8 12.0 ± 4.1 12.0 ± 3.6 0.79
FIO2 (%), median (IQR) 50 (40–60) 45 (35–60) 50 (40–65)  < 0.001
PEEP (cmH2O), median (IQR) 10 (8–12) 10 (8–12) 10 (8–12) 0.647
Plateau pressure (cmH2O), mean (SD) 22 ± 5 22 ± 5 23 ± 5 0.033
Driving pressure (cmH2O), mean (SD) 13 ± 4 12 ± 4 13 ± 4 0.017
Compliance (mLcmH2O−1), median (IQR) 31.9 (24.4–40.9) 32.9 (25.0–42.0) 31.7 (23.4–40.0) 0.063
Compliance (mLcmH2O−1.Kg−1 ibw), median (IQR) 0.51 (0.41–0.65) 0.54 (0.42–0.67) 0.50 (0.40–0.64) 0.027
PaO2/FIO2 (%), mean (SD) 171 ± 74 178 ± 73 165 ± 75 0.004
Arterial pH, mean (SD) 7.35 ± 0.09 7.37 ± 0.09 7.33 ± 0.10  < 0.001
Arterial PaCO2 (mmHg), mean (SD) 44 ± 10 44 ± 9 45 ± 11 0.07
Arterial oxygen saturation (%), mean (SD) 93 ± 5 93 ± 4 92 ± 6 0.002
Rescue therapy for respiratory failure     
 Prone position 154 (16) 82 (17) 72 (14) 0.577
 Recruitment maneuvers 15 (2) 8 (2) 7 (1) 1.000
 PEEP titration 111 (11) 61 (13) 50 (10) 0.950
 Inhaled nitric oxide 2 (0) 2 (0) 0 (0) 0.582
 Extracorporeal membrane oxygenation 4 (0) 1 (0) 3 (1) 0.678
  1. SD: standard deviation; IQR: interquartile range; O2: oxygen; FIO2: inspired fraction of oxygen; PEEP: positive end-expiratory pressure; ibw: ideal body weight; PaO2/FIO2: arterial partial pressure of oxygen divided by the inspired fraction of oxygen. Data are n. (%), unless otherwise stated. PaO2/FIO2 was missing for 5 patients; Plateau pressure (cmH2O) and Driving pressure (cmH2O) were missing for 109 patients; PaCO2: arterial partial pressure of carbon dioxide was missing for 59 patients; arterial pH and arterial oxygen saturation were missing for 59 patients. Comparisons were made with t test, Mann–Whitney U tests or Chi-square test as appropriate