Skip to main content

Table 2 Ventilatory management on the first 24 h after ICU admission, according to outcome at 28 days

From: Protective ventilation and outcomes of critically ill patients with COVID-19: a cohort study

Management

All, n = 984

Survivors, n = 471

Nonsurvivors, n = 513

p value

Tidal volume (mL/Kg ideal body weight), mean (SD)

6.5 ± 1.3

6.5 ± 1.3

6.5 ± 1.3

0.82

Minute volume (L/min), mean (SD)

12.0 ± 3.8

12.0 ± 4.1

12.0 ± 3.6

0.79

FIO2 (%), median (IQR)

50 (40–60)

45 (35–60)

50 (40–65)

 < 0.001

PEEP (cmH2O), median (IQR)

10 (8–12)

10 (8–12)

10 (8–12)

0.647

Plateau pressure (cmH2O), mean (SD)

22 ± 5

22 ± 5

23 ± 5

0.033

Driving pressure (cmH2O), mean (SD)

13 ± 4

12 ± 4

13 ± 4

0.017

Compliance (mLcmH2O−1), median (IQR)

31.9 (24.4–40.9)

32.9 (25.0–42.0)

31.7 (23.4–40.0)

0.063

Compliance (mLcmH2O−1.Kg−1 ibw), median (IQR)

0.51 (0.41–0.65)

0.54 (0.42–0.67)

0.50 (0.40–0.64)

0.027

PaO2/FIO2 (%), mean (SD)

171 ± 74

178 ± 73

165 ± 75

0.004

Arterial pH, mean (SD)

7.35 ± 0.09

7.37 ± 0.09

7.33 ± 0.10

 < 0.001

Arterial PaCO2 (mmHg), mean (SD)

44 ± 10

44 ± 9

45 ± 11

0.07

Arterial oxygen saturation (%), mean (SD)

93 ± 5

93 ± 4

92 ± 6

0.002

Rescue therapy for respiratory failure

    

 Prone position

154 (16)

82 (17)

72 (14)

0.577

 Recruitment maneuvers

15 (2)

8 (2)

7 (1)

1.000

 PEEP titration

111 (11)

61 (13)

50 (10)

0.950

 Inhaled nitric oxide

2 (0)

2 (0)

0 (0)

0.582

 Extracorporeal membrane oxygenation

4 (0)

1 (0)

3 (1)

0.678

  1. SD: standard deviation; IQR: interquartile range; O2: oxygen; FIO2: inspired fraction of oxygen; PEEP: positive end-expiratory pressure; ibw: ideal body weight; PaO2/FIO2: arterial partial pressure of oxygen divided by the inspired fraction of oxygen. Data are n. (%), unless otherwise stated. PaO2/FIO2 was missing for 5 patients; Plateau pressure (cmH2O) and Driving pressure (cmH2O) were missing for 109 patients; PaCO2: arterial partial pressure of carbon dioxide was missing for 59 patients; arterial pH and arterial oxygen saturation were missing for 59 patients. Comparisons were made with t test, Mann–Whitney U tests or Chi-square test as appropriate