From: Protective ventilation and outcomes of critically ill patients with COVID-19: a cohort study
Management | All, n = 984 | Survivors, n = 471 | Nonsurvivors, n = 513 | p value |
---|---|---|---|---|
Tidal volume (mL/Kg ideal body weight), mean (SD) | 6.5 ± 1.3 | 6.5 ± 1.3 | 6.5 ± 1.3 | 0.82 |
Minute volume (L/min), mean (SD) | 12.0 ± 3.8 | 12.0 ± 4.1 | 12.0 ± 3.6 | 0.79 |
FIO2 (%), median (IQR) | 50 (40–60) | 45 (35–60) | 50 (40–65) |  < 0.001 |
PEEP (cmH2O), median (IQR) | 10 (8–12) | 10 (8–12) | 10 (8–12) | 0.647 |
Plateau pressure (cmH2O), mean (SD) | 22 ± 5 | 22 ± 5 | 23 ± 5 | 0.033 |
Driving pressure (cmH2O), mean (SD) | 13 ± 4 | 12 ± 4 | 13 ± 4 | 0.017 |
Compliance (mLcmH2O−1), median (IQR) | 31.9 (24.4–40.9) | 32.9 (25.0–42.0) | 31.7 (23.4–40.0) | 0.063 |
Compliance (mLcmH2O−1.Kg−1 ibw), median (IQR) | 0.51 (0.41–0.65) | 0.54 (0.42–0.67) | 0.50 (0.40–0.64) | 0.027 |
PaO2/FIO2 (%), mean (SD) | 171 ± 74 | 178 ± 73 | 165 ± 75 | 0.004 |
Arterial pH, mean (SD) | 7.35 ± 0.09 | 7.37 ± 0.09 | 7.33 ± 0.10 |  < 0.001 |
Arterial PaCO2 (mmHg), mean (SD) | 44 ± 10 | 44 ± 9 | 45 ± 11 | 0.07 |
Arterial oxygen saturation (%), mean (SD) | 93 ± 5 | 93 ± 4 | 92 ± 6 | 0.002 |
Rescue therapy for respiratory failure | Â | Â | Â | Â |
 Prone position | 154 (16) | 82 (17) | 72 (14) | 0.577 |
 Recruitment maneuvers | 15 (2) | 8 (2) | 7 (1) | 1.000 |
 PEEP titration | 111 (11) | 61 (13) | 50 (10) | 0.950 |
 Inhaled nitric oxide | 2 (0) | 2 (0) | 0 (0) | 0.582 |
 Extracorporeal membrane oxygenation | 4 (0) | 1 (0) | 3 (1) | 0.678 |