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Annals of Intensive Care

Table 1 Characteristics of the population on ICU/ICW admission

From: Seasonal burden of severe influenza virus infection in the critically ill patients, using the Assistance Publique-Hôpitaux de Paris clinical data warehouse: a pilot study

Variable

All participants

n = 320

Survivors

n = 257

Non-survivors

n = 63

Age (years), median [IQR]

63.2 [52.30–73.4]

62.6 [50.3–71.3]

69.0 [60.0–81.0]

Age > 65 years

147 (45.6)

110 (42.8)

37 (58.7)

Sex (male), n (%)

188 (58.8)

148 (57.6)

40 (63.5)

Obesitya, n (%)

29 (9.1)

23 (8.9)

6 (9.5)

Comorbid conditions, n (%)

130 (40.6)

99 (38.6)

31 (49.2)

 Neoplastic disease

42 (13.1)

30 (11.7)

12 (19.0)

 Congestive heart failure

54 (16.9)

43 (16.7)

11 (17.5)

 Cerebrovascular disease

16 (5)

11 (4.3)

5 (7.9)

 Renal disease

53 (16.6)

39 (15.2)

14 (22.2)

 Liver disease

5 (1.6)

2 (0.8)

3 (4.8)

Influenza vaccinationb, n (%)

52 (21.2)

43 (21.5)

9 (20.0)

At least one factor targeted by the vaccination c, n (%)

270 (84.4)

212 (82.5)

58 (92.1)

Origin, n (%)

   

 Emergency department

153 (47.8)

121 (47.1)

32 (50.8)

 Other hospital wards

22 (6.9)

18 (7.0)

4 (6.3)

 Nursing home residence

11 (3.4)

9 (3.5)

2 (3.2)

 Out-of-hospital emergency services

134 (41.9)

109 (42.4)

25 (39.7)

Healthcare worker

2 (0.6)

1 (0.4)

1 (1.6)

Information before ICU/ICW admission, n (%)

 Time from symptoms onset to ICU/ICW referral (days), median [IQR]

3 [1–5]

3 [1–5]

3 [1–6]

 Treatments before admission, n (%)

220 (69.4)

179 (70.2)

41 (67.2)

  Antimicrobial drugs

196 (61.3)

160 (62.3)

36 (57.1)

   Antibiotics

179 (56.5)

146 (57.3)

33 (53.2)

   Antiviral therapy (oseltamivir)

76 (24.0)

64 (25.1)

12 (19.4)

  Anti-inflammatory drugs

53 (16.6)

44 (17.1)

9 (14.3)

   Steroids

39 (12.3)

33 (12.9)

6 (9.7)

   NSAIDs

17 (5.4)

13 (5.1)

4 (6.5)

Clinical features during the first 24 h of ICU/ICW admission, n (%)

 Altered mental status (CGS < 14)

83 (28.2)

66 (27.8)

17 (29.8)

 Pulse ≥ 125 per minute

92 (28.8)

72 (27.9)

20 (32.4)

 Respiratory rate ≥ 30 per minute or MV

211 (65.9)

165 (64.0)

46 (73.8)

 Systolic blood pressure < 90 mm Hg or diastolic blood pressure < 60 mm Hg or vasopressors

116 (36.2)

81 (31.3)

35 (56.0)

 Temperature < 35 °C or ≥ 40 °C

41 (13.0)

23 (9.0)

18 (29.5)

Radiographic findings during the first 24 h of ICU/ICW admission, n (%)

 Bilateral infiltrate

200 (62.5)

153 (59.5)

47 (74.6)

 Pleural effusion

42 (13.1)

30 (11.7)

12 (19.0)

  1. Percentages were calculated after removing observations with missing data
  2. CGS Coma Glasgow scale, ICU intensive care unit, ICW intermediate care wards, MV mechanical ventilation, NSAIDs non-steroidal anti-inflammatory drugs
  3. aObesity defined as Body Mass Index (kg/m2) > 30 kg/m2
  4. bHistory of influenza vaccination was the variable with the largest amount of missing data; the reported percentages are 43/(257 − 57) = 21.5%, 9/(63 − 18) = 20.0% and 52/(320 − 75) = 21.2%
  5. cPregnancy, obesity (BMI > 30), 65-year old subjects and over, nursing home residency regardless of age, type 1 and 2 diabetes, chronic respiratory disease (chronic broncho-pulmonary diseases including asthma, broncho-pulmonary dysplasia and cystic fibrosis, chronic respiratory insufficiency), cardiac disease (congenital heart disease, heart failure, valvular disease, severe arrhythmia, coronary disease), neurological or muscle disease (stroke, severe forms of neurological and muscular disorders, para and tetraplegia with diaphragmatic involvement), renal disease (severe chronic renal insufficiency, nephrotic syndrome), immunosuppressive state (primary or acquired immune deficiency, except regular treatment with immunoglobulins, HIV infection and AIDS, solid transplantation), and others (hepatopathy, sickle cell disease, healthcare professionals) (see Additional file 1: Table S2)
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