From: Myeloid phenotypes in severe COVID-19 predict secondary infection and mortality: a pilot study
Hyper-activated monocytes/macrophage (HAMM) | Transient immune-depression (TID) | Persistent immune-depression (PID) | |
---|---|---|---|
Dynamic diagnostic criteria | |||
M-MDSC day 0a,b | < 5% | ||
mHLA-DR day 0a | > 30,000 AB/C | < 30,000 AB/C | |
mHLA-DR day 5–7a | > 15,000 AB/C | < 15,000 AB/C | |
Targeted investigation | Screen for MAS-like: myelogram | Track VAP | |
Targeted therapy | If MAS-like, consider immunotherapy (e.g. Anti-IL6) | Consider empiric antibiotics by day 5–7 |