From: Platelet activation in critically ill COVID-19 patients
Characteristics | All patients | Disease severity | p value | ||
---|---|---|---|---|---|
N = 60 | Mild-to-moderate | Severe | Critical | ||
N = 35 | N = 10 | N = 15 | |||
Age, median (IQR), year | 58.50 [49.00, 72.25] | 59.00 [47.50, 74.00] | 58.00 [47.25, 70.00] | 58.00 [54.00, 68.50] | 0.98 |
Male, no. (%) | 46 (76.7) | 22 (62.9) | 10 (100.0) | 14 (93.3) | 0.011 |
Median interval from first symptoms | 6.0 [4.0, 8.0] | 6.0 [3.0, 7.0] | 4.0 [4.0, 7.5] | 7.0 [6.5, 9.0] | 0.063 |
Coexisting disorder, no. (%) | |||||
Any | 18 (51.4) | 5 (50.0) | 11 (73.3) | 0.18 | |
COPD | 1 (1.7) | 0 (0.0) | 0 (0.0) | 1 (6.7) | 0.21 |
Diabetes | 16 (26.7) | 8 (22.9) | 3 (30.0) | 5 (33.3) | 0.72 |
Hypertension | 27 (45.0) | 14 (40.0) | 5 (50.0) | 8 (53.3) | 0.65 |
Cardiovascular disease | 12 (20.0) | 5 (14.2) | 3 (30.0) | 4 (26.7) | 0.26 |
Cancer or hemopathy | 3 (5.0) | 3 (8.6) | 0 (0.0) | 0 (0.0) | 0.32 |
Chronic renal disease | 8 (13.3) | 4 (11.4) | 3 (30.0) | 1 (6.7) | 0.21 |
Overweight | 39 (65.0) | 19 (54.3) | 7 (70.0) | 13 (86.7) | 0.026 |
Fever on admission | |||||
Median temperature (IQR), °C | 38.20 [37.70, 38.80] | 38.20 [37.80, 38.70] | 38.00 [37.60, 38.35] | 38.70 [37.40, 39.00] | 0.53 |
Symptoms on admission no. (%) | |||||
Fever | 58 (96.7 ) | 34 (97.1 ) | 9 (90.0) | 15 (100) | 0.38 |
Cough | 50 (83.3) | 32 (91.4) | 7 (70.0) | 11 (73.3) | 0.14 |
Dyspnea | 43 (71.7) | 21 (60.0) | 8 (80.0) | 15 (100) | 0.046 |
Fatigue | 42 (70.0) | 21 (60.0) | 8 (80.0) | 15 (100) | 0.36 |
Myalgia | 24 (40.0) | 15 (42.9) | 4 (40.0) | 5 (33.3) | 0.87 |
Diarrhea | 16 (26.7) | 10 (28.6) | 3 (30.0) | 3 (20.0) | 0.79 |
Median oxygen requirement (IQR, L/min) | 3.00 [2.00, 5.00] | 2.00 [1.25, 2.00] | 4.00 [4.00, 5.00] | MV | – |
Clinical outcomes, no. (%) | |||||
Thrombotic event (%) | 8 (13.3) | 3 (8.6) | 2 (20.0) | 3 (20.0) | 0.44 |
Clinical worsening requiring MV (%) | – | 11 (31.4) | 3 (30.0) | – | – |
Death (%) | 17 (28.3) | 4 (11.4) | 2 (20.0) | 11 (73.3) | < 0.001 |
Laboratory findings on admission | |||||
Leukocytes (IQR), × 109/L | 5.75 [4.47, 7.77] | 5.40 [4.15, 6.85] | 6.35 [5.05, 10.92] | 7.60 [4.90, 11.90] | 0.041 |
Neutrophils (IQR), × 109/L | 4.36 [3.13, 6.83] | 3.74 [2.84, 5.18] | 5.43 [3.89, 10.86] | 6.99 [3.88, 10.48] | 0.015 |
Lymphocytes (IQR), × 109/L | 0.85 [0.62, 1.15] | 0.88 [0.71, 1.10] | 0.85 [0.57, 1.25] | 0.60 [0.46, 1.05] | 0.19 |
Monocytes (IQR), × 109/L | 0.35 [0.24, 0.49] | 0.35 [0.25, 0.48] | 0.43 [0.35, 0.59] | 0.26 [0.16, 0.53] | 0.26 |
Platelets (IQR), × 109/L | 164 [124, 221] | 165 [124, 216] | 167 [135, 242] | 162 [127.00, 258] | 0.79 |
CRP (IQR), mg/L | 104 [62, 168] | 86 [38, 120] | 117 [109, 184] | 161 [98, 207] | 0.005 |
Lactate dehydrogenase (IQR), U/L | – | – | – | – | |
Fibrinogen (mean (SD)), g/L | 5.83 [4.90, 6.50] | 5.30 [4.62, 6.30] | 6.80 [5.85, 7.38] | 6.30 [5.65, 7.00] | 0.006 |
DDimer (mean (SD)), ng/ml | 999 [662, 1724] | 789 [537, 1270] | 1145 [759, 2142] | 1170 [988, 2151] | 0.05 |
Soluble Pselectine, pg/mL | 23663 [18693, 30394] | 20556 [17484, 29677] | 25239 [21637, 28565] | 27041 [24171, 38934] | 0.048 |