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Table 1 Clinical characteristics and laboratory findings of patients from Cohort 1

From: Platelet activation in critically ill COVID-19 patients

Characteristics

All patients

Disease severity 

p value

 

N = 60

Mild-to-moderate

Severe

Critical

 
  

N = 35

N = 10

N = 15

 

Age, median (IQR), year

58.50 [49.00, 72.25]

59.00 [47.50, 74.00]

58.00 [47.25, 70.00]

58.00 [54.00, 68.50]

0.98

Male, no. (%)

46 (76.7)

22 (62.9)

10 (100.0)

14 (93.3)

0.011

Median interval from first symptoms

6.0 [4.0, 8.0]

6.0 [3.0, 7.0]

4.0 [4.0, 7.5]

7.0 [6.5, 9.0]

0.063

Coexisting disorder, no. (%)

     

 Any

 

18 (51.4)

5 (50.0)

11 (73.3)

0.18

 COPD

1 (1.7)

0 (0.0)

0 (0.0)

1 (6.7)

0.21

 Diabetes

16 (26.7)

8 (22.9)

3 (30.0)

5 (33.3)

0.72

 Hypertension

27 (45.0)

14 (40.0)

5 (50.0)

8 (53.3)

0.65

 Cardiovascular disease

12 (20.0)

5 (14.2)

3 (30.0)

4 (26.7)

0.26

 Cancer or hemopathy

3 (5.0)

3 (8.6)

0 (0.0)

0 (0.0)

0.32

 Chronic renal disease

8 (13.3)

4 (11.4)

3 (30.0)

1 (6.7)

0.21

 Overweight

39 (65.0)

19 (54.3)

7 (70.0)

13 (86.7)

0.026

Fever on admission

     

 Median temperature (IQR), °C

38.20 [37.70, 38.80]

38.20 [37.80, 38.70]

38.00 [37.60, 38.35]

38.70 [37.40, 39.00]

0.53

Symptoms on admission no. (%)

     

 Fever

58 (96.7 )

34 (97.1 )

9 (90.0)

15 (100)

0.38

 Cough

50 (83.3)

32 (91.4)

7 (70.0)

11 (73.3)

0.14

 Dyspnea

43 (71.7)

21 (60.0)

8 (80.0)

15 (100)

0.046

 Fatigue

42 (70.0)

21 (60.0)

8 (80.0)

15 (100)

0.36

 Myalgia

24 (40.0)

15 (42.9)

4 (40.0)

5 (33.3)

0.87

 Diarrhea

16 (26.7)

10 (28.6)

3 (30.0)

3 (20.0)

0.79

 Median oxygen requirement (IQR, L/min)

3.00 [2.00, 5.00]

2.00 [1.25, 2.00]

4.00 [4.00, 5.00]

MV

Clinical outcomes, no. (%)

     

 Thrombotic event (%)

8 (13.3)

3 (8.6)

2 (20.0)

3 (20.0)

0.44

 Clinical worsening requiring MV (%)

11 (31.4)

3 (30.0)

 Death (%)

17 (28.3)

4 (11.4)

2 (20.0)

11 (73.3)

< 0.001

Laboratory findings on admission

     

 Leukocytes (IQR), × 109/L

5.75 [4.47, 7.77]

5.40 [4.15, 6.85]

6.35 [5.05, 10.92]

7.60 [4.90, 11.90]

0.041

 Neutrophils (IQR), × 109/L

4.36 [3.13, 6.83]

3.74 [2.84, 5.18]

5.43 [3.89, 10.86]

6.99 [3.88, 10.48]

0.015

 Lymphocytes (IQR), × 109/L

0.85 [0.62, 1.15]

0.88 [0.71, 1.10]

0.85 [0.57, 1.25]

0.60 [0.46, 1.05]

0.19

 Monocytes (IQR), × 109/L

0.35 [0.24, 0.49]

0.35 [0.25, 0.48]

0.43 [0.35, 0.59]

0.26 [0.16, 0.53]

0.26

 Platelets (IQR), × 109/L

164 [124, 221]

165 [124, 216]

167 [135, 242]

162 [127.00, 258]

0.79

 CRP (IQR), mg/L

104 [62, 168]

86 [38, 120]

117 [109, 184]

161 [98, 207]

0.005

 Lactate dehydrogenase (IQR), U/L

 

 Fibrinogen (mean (SD)), g/L

5.83 [4.90, 6.50]

5.30 [4.62, 6.30]

6.80 [5.85, 7.38]

6.30 [5.65, 7.00]

0.006

 DDimer (mean (SD)), ng/ml

999 [662, 1724]

789 [537, 1270]

1145 [759, 2142]

1170 [988, 2151]

0.05

 Soluble Pselectine, pg/mL

23663 [18693, 30394]

20556 [17484, 29677]

25239 [21637, 28565]

27041 [24171, 38934]

0.048

  1. Significant values (p < 0.05) are emphasized in bold
  2. Quantitative variables are described as median (interquartile range) and compared using the Kruskal–Wallis test; qualitative variables are described as n (%) and compared using the χ2 test of independence
  3. COPD chronic obstructive pulmonary disease, CRP C-reactive protein, IQR interquartile range, MV mechanical ventilation