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Table 1 Clinical characteristics and laboratory findings of patients from Cohort 1

From: Platelet activation in critically ill COVID-19 patients

Characteristics All patients Disease severity  p value
  N = 60 Mild-to-moderate Severe Critical  
   N = 35 N = 10 N = 15  
Age, median (IQR), year 58.50 [49.00, 72.25] 59.00 [47.50, 74.00] 58.00 [47.25, 70.00] 58.00 [54.00, 68.50] 0.98
Male, no. (%) 46 (76.7) 22 (62.9) 10 (100.0) 14 (93.3) 0.011
Median interval from first symptoms 6.0 [4.0, 8.0] 6.0 [3.0, 7.0] 4.0 [4.0, 7.5] 7.0 [6.5, 9.0] 0.063
Coexisting disorder, no. (%)      
 Any   18 (51.4) 5 (50.0) 11 (73.3) 0.18
 COPD 1 (1.7) 0 (0.0) 0 (0.0) 1 (6.7) 0.21
 Diabetes 16 (26.7) 8 (22.9) 3 (30.0) 5 (33.3) 0.72
 Hypertension 27 (45.0) 14 (40.0) 5 (50.0) 8 (53.3) 0.65
 Cardiovascular disease 12 (20.0) 5 (14.2) 3 (30.0) 4 (26.7) 0.26
 Cancer or hemopathy 3 (5.0) 3 (8.6) 0 (0.0) 0 (0.0) 0.32
 Chronic renal disease 8 (13.3) 4 (11.4) 3 (30.0) 1 (6.7) 0.21
 Overweight 39 (65.0) 19 (54.3) 7 (70.0) 13 (86.7) 0.026
Fever on admission      
 Median temperature (IQR), °C 38.20 [37.70, 38.80] 38.20 [37.80, 38.70] 38.00 [37.60, 38.35] 38.70 [37.40, 39.00] 0.53
Symptoms on admission no. (%)      
 Fever 58 (96.7 ) 34 (97.1 ) 9 (90.0) 15 (100) 0.38
 Cough 50 (83.3) 32 (91.4) 7 (70.0) 11 (73.3) 0.14
 Dyspnea 43 (71.7) 21 (60.0) 8 (80.0) 15 (100) 0.046
 Fatigue 42 (70.0) 21 (60.0) 8 (80.0) 15 (100) 0.36
 Myalgia 24 (40.0) 15 (42.9) 4 (40.0) 5 (33.3) 0.87
 Diarrhea 16 (26.7) 10 (28.6) 3 (30.0) 3 (20.0) 0.79
 Median oxygen requirement (IQR, L/min) 3.00 [2.00, 5.00] 2.00 [1.25, 2.00] 4.00 [4.00, 5.00] MV
Clinical outcomes, no. (%)      
 Thrombotic event (%) 8 (13.3) 3 (8.6) 2 (20.0) 3 (20.0) 0.44
 Clinical worsening requiring MV (%) 11 (31.4) 3 (30.0)
 Death (%) 17 (28.3) 4 (11.4) 2 (20.0) 11 (73.3) < 0.001
Laboratory findings on admission      
 Leukocytes (IQR), × 109/L 5.75 [4.47, 7.77] 5.40 [4.15, 6.85] 6.35 [5.05, 10.92] 7.60 [4.90, 11.90] 0.041
 Neutrophils (IQR), × 109/L 4.36 [3.13, 6.83] 3.74 [2.84, 5.18] 5.43 [3.89, 10.86] 6.99 [3.88, 10.48] 0.015
 Lymphocytes (IQR), × 109/L 0.85 [0.62, 1.15] 0.88 [0.71, 1.10] 0.85 [0.57, 1.25] 0.60 [0.46, 1.05] 0.19
 Monocytes (IQR), × 109/L 0.35 [0.24, 0.49] 0.35 [0.25, 0.48] 0.43 [0.35, 0.59] 0.26 [0.16, 0.53] 0.26
 Platelets (IQR), × 109/L 164 [124, 221] 165 [124, 216] 167 [135, 242] 162 [127.00, 258] 0.79
 CRP (IQR), mg/L 104 [62, 168] 86 [38, 120] 117 [109, 184] 161 [98, 207] 0.005
 Lactate dehydrogenase (IQR), U/L  
 Fibrinogen (mean (SD)), g/L 5.83 [4.90, 6.50] 5.30 [4.62, 6.30] 6.80 [5.85, 7.38] 6.30 [5.65, 7.00] 0.006
 DDimer (mean (SD)), ng/ml 999 [662, 1724] 789 [537, 1270] 1145 [759, 2142] 1170 [988, 2151] 0.05
 Soluble Pselectine, pg/mL 23663 [18693, 30394] 20556 [17484, 29677] 25239 [21637, 28565] 27041 [24171, 38934] 0.048
  1. Significant values (p < 0.05) are emphasized in bold
  2. Quantitative variables are described as median (interquartile range) and compared using the Kruskal–Wallis test; qualitative variables are described as n (%) and compared using the χ2 test of independence
  3. COPD chronic obstructive pulmonary disease, CRP C-reactive protein, IQR interquartile range, MV mechanical ventilation