Table 1 Oxygenation, lung mechanics, maximum pressure swings, and other injury indicators generated in our COVID-19 model for different levels of respiratory effort on 100% oxygen, data presents mean ± sd across the population of 10 patients
|  | VT = 7 (ml/kg) RR = 14 (bpm) | VT = 7 (ml/kg) RR = 20 (bpm) | VT = 7 (ml/kg) RR = 30 (bpm) | VT = 10 (ml/kg) RR = 14 (bpm) | VT = 10 (ml/kg) RR = 20 (bpm) | VT = 10 (ml/kg) RR = 30 (bpm) |
|---|---|---|---|---|---|---|
\({P}_{MIN}\)(cmH2O) | − 12.4 ± 0.3 | − 17.4 ± 0.3 | − 25.3 ± 0.2 | − 17.8 ± 0.4 | − 24.5 ± 0.4 | − 35.4 ± 0.2 |
SaO2 (%) | 83.8 ± 5.1 | 84.1 ± 5 | 93.5 ± 1.4 | 84.1 ± 5 | 89.7 ± 2.3 | 97.6 ± 0.8 |
PaO2 (mmHg) | 52.6 ± 7.1 | 49.2 ± 6.2 | 66.7 ± 4.7 | 48.9 ± 6.3 | 55.8 ± 4.4 | 98.4 ± 13.2 |
PF ratio (mmHg) | 52.6 ± 7.1 | 49.2 ± 6.2 | 66.7 ± 4.7 | 48.9 ± 6.3 | 55.8 ± 4.4 | 98.4 ± 13.2 |
Phys. Shunt (%) | 48.9 ± 4.7 | 48.8 ± 4.7 | 38.5 ± 1.7 | 48.8 ± 4.7 | 43.5 ± 2.6 | 31.7 ± 1.7 |
Phys. VD (ml) | 187.4 ± 5.6 | 185.6 ± 6.6 | 187 ± 4.5 | 258.5 ± 10.5 | 255 ± 8.6 | 255.1 ± 6.6 |
VD/VT | 0.38 ± 0.01 | 0.38 ± 0.01 | 0.38 ± 0.01 | 0.37 ± 0.02 | 0.37 ± 0.01 | 0.37 ± 0.01 |
PaCO2 (mmHg) | 51.8 ± 1.5 | 37.3 ± 1.6 | 25 ± 0.6 | 36.4 ± 1.5 | 25.9 ± 0.8 | 17.2 ± 0.4 |
EELV (ml) | 1678.9 ± 35.3 | 1773.5 ± 36.3 | 1933.6 ± 37.3 | 1718.8 ± 35.7 | 1844.9 ± 34.5 | 2064.6 ± 31 |
VT (ml) | 487.7 ± 2.1 | 487.9 ± 2.2 | 489.6 ± 0.7 | 695.9 ± 1.9 | 695 ± 2.8 | 697.5 ± 1.3 |
Compliance (ml/cmH2O) | 63 ± 1.4 | 39.6 ± 0.9 | 25 ± 0.3 | 64.7 ± 1.4 | 41.3 ± 0.7 | 26 ± 0.3 |
DP (cmH2O) | 7.7 ± 0.2 | 12.3 ± 0.2 | 19.6 ± 0.2 | 10.8 ± 0.2 | 16.8 ± 0.3 | 26.9 ± 0.3 |
Power (J/min) | 1.6 ± 0.1 | 4.7 ± 0.1 | 12.9 ± 0.2 | 3.0 ± 0.1 | 8.9 ± 0.2 | 24.9 ± 0.3 |
Total Strain | 0.29 ± 0.006 | 0.35 ± 0.005 | 0.44 ± 0.008 | 0.44 ± 0.008 | 0.51 ± 0.011 | 0.65 ± 0.016 |
\(\Delta \) PPL (cmH2O) | 12.0 ± 0.3 | 21.6 ± 0.5 | 33.8 ± 0.4 | 16.8 ± 0.4 | 29.2 ± 0.5 | 46.2 ± 0.5 |
\(\Delta \) PTP (cmH2O) | 4.7 ± 0.1 | 9.8 ± 0.2 | 17.9 ± 0.3 | 6.3 ± 0.2 | 13.1 ± 0.3 | 24.2 ± 0.3 |