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Table 2 Factors associated with case fatality in COVID-19 patients admitted in the ICU in France, March, 1st to May, 31st 2020, analyzed by logistic regression model

From: Case fatality inequalities of critically ill COVID-19 patients according to patient-, hospital- and region-related factors: a French nationwide study

  Univariate Multivariate
N = 14,513 N =  14,232  
  p Adjusted OR 95% CI p
Patient level     
Age     
 < 65 y–o < .0001 Ref   
 65–79 y–o 2.5 [2.3–2.8] < .0001
 ≥ 80 y–o 10.2 [8.7–12] < .0001
Sex     
 Female 0.0009 1.1 [1–1.2] 0.16
SAPS II*     
 < 30  < .0001 Ref   
 [30–40] 1.4 [1.3–1.6] < .0001
 ≥ 40 2.3 [2.1–2.6] < .0001
Comorbid conditions    
 0  < .0001 Ref   
 1 1.0 [0.9–1.2] 0.9
 2 1.0 [0.9–1.1] 1.0
 ≥ 3 1.2 [1.0–1.3] 0.01
ICU specific care supports    
 Invasive ventilation < .0001 1.7 [1.5–1.9] < .0001
 Vasoactive treatment** < .0001 1.7 [1.5–1.9] < .0001
 Renal replacement therapy < .0001 2.9 [2.6–3.2] < .0001
 ECMO < .0001 2.9 [2.4–3.5] < .0001
Hospital level     
Number of ICU stays in hospital 2019, age ≥ 18 y–o***   
< 100 0.003 1.3 [1.1–1.4]  < .0001
 [1000–2000] 1.0 [0.9–1.2] 0.73
 ≥ 2000 Ref   
Regional level     
Number of days with 75% or more of ICU beds occupied by COVID-19 patients
 < 10 days  < .0001 Ref   
 10–19 days 1.2 [1.0–1.5] 0.03
 20–29 days 1.5 [1.2–1.7]  < .0001
 ≥ 30 days 2.2 [1.9–2.6]  < .0001
  1. *Missing data SAPS II n = 281
  2. **Dobutamine, dopamine, epinephrine, norepinephrine
  3. ***For hospitals with several ICUs, all ICU stays were included