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Table 2 Univariate cause-specific hazard ratio of invasive candida infection (competing risks: death, censored: alive discharge from ICU)

From: Monocyte human leukocyte antigen-DR but not β-d-glucan may help early diagnosing invasive Candida infection in critically ill patients

  Cause-specific HR of invasive Candida infection Cause-specific HR of death
  Cs-HR 95%CI Cs-HR 95%CI
Past history of cancer 7.17 [1.38–37.36] 1.38 [0.25–7.61]
SAPS II (time-dependent) 1.06 [1.01–1.11] 1.01 [0.96–1.07]
SOFA score (time-dependent) 1.33 [1.08–1.62] 1.5 [1.06–2.13]
Immunological markers (time-dependent)     
 Total lymphocytes < 1100/mm3 1.24 [0.15–10.29] 1.04 [0.12–8.96]
 Total lymphocytes < 500/mm3 3.83 [0.74–19.81] 1.49 [0.3–7.4]
 CD4+ T cells < 200/mm3 4.49 [0.87–23.23] 3.6 [0.66–19.67]
 CD8+ T cells < 80/mm3 0.74 [0.16–3.31] 6.56 [0.79–54.55]
 NK cells < 60/mm3 1.24 [0.23–6.7] 0.52 [0.11–2.44]
 mHLA-DR < 5000 Ab/cells 6.56 [1.24–34.61] 2.15 [0.43–10.68]
 mHLA-DR < 8000 Ab/cells 6.83 [0.81–57.53] 4.42 [0.52–37.95]
Fungals markers (time-dependent)     
 Empiric antifungal therapy 1.15 [0.25–5.22] 0.31 [0.04–2.56]
 Beta-d-glucan > 80 pg/mL 0.63 [0.14–2.86] 2.07 [0.4–10.77]
 Candida score (total score) 2.09 [0.74–5.92] 0.43 [0.19–0.96]
 Number of Candida colonization sites 1.17 [0.59–2.32] 1.52 [0.68–3.37]
 Colonization index > 0.5 4.1 [0.38–44.5] 2.91 [0.23–36.23]
  1. Evaluation of time-dependent mycological and immunological markers after septic shock and inclusion (from day 2 to day 14)
  2. SAPS Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment, mHLA-DR monocytic human leucocyte antigen DR