Monocyte human leukocyte antigen-DR but not β-d-glucan may help early diagnosing invasive Candida infection in critically ill patients

Annals of Intensive Care

Table 2 Univariate cause-specific hazard ratio of invasive candida infection (competing risks: death, censored: alive discharge from ICU)

	Cause-specific HR of invasive Candida infection		Cause-specific HR of death
	Cs-HR	95%CI	Cs-HR	95%CI
Past history of cancer	7.17	[1.38–37.36]	1.38	[0.25–7.61]
SAPS II (time-dependent)	1.06	[1.01–1.11]	1.01	[0.96–1.07]
SOFA score (time-dependent)	1.33	[1.08–1.62]	1.5	[1.06–2.13]
Immunological markers (time-dependent)
Total lymphocytes < 1100/mm³	1.24	[0.15–10.29]	1.04	[0.12–8.96]
Total lymphocytes < 500/mm³	3.83	[0.74–19.81]	1.49	[0.3–7.4]
CD4+ T cells < 200/mm³	4.49	[0.87–23.23]	3.6	[0.66–19.67]
CD8+ T cells < 80/mm³	0.74	[0.16–3.31]	6.56	[0.79–54.55]
NK cells < 60/mm³	1.24	[0.23–6.7]	0.52	[0.11–2.44]
mHLA-DR < 5000 Ab/cells	6.56	[1.24–34.61]	2.15	[0.43–10.68]
mHLA-DR < 8000 Ab/cells	6.83	[0.81–57.53]	4.42	[0.52–37.95]
Fungals markers (time-dependent)
Empiric antifungal therapy	1.15	[0.25–5.22]	0.31	[0.04–2.56]
Beta-d-glucan > 80 pg/mL	0.63	[0.14–2.86]	2.07	[0.4–10.77]
Candida score (total score)	2.09	[0.74–5.92]	0.43	[0.19–0.96]
Number of Candida colonization sites	1.17	[0.59–2.32]	1.52	[0.68–3.37]
Colonization index > 0.5	4.1	[0.38–44.5]	2.91	[0.23–36.23]

Evaluation of time-dependent mycological and immunological markers after septic shock and inclusion (from day 2 to day 14)
SAPS Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment, mHLA-DR monocytic human leucocyte antigen DR