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Table 3 Predictive value of fungal and immunological markers

From: Monocyte human leukocyte antigen-DR but not β-d-glucan may help early diagnosing invasive Candida infection in critically ill patients

  Sensitivity
(95% CI)
Specificity
(95% CI)
PPV
(95% CI)
NPV
(95% CI)
Past history of cancer 70 [41–98] 82.5 [70–94] 50.0 [23–76] 91.7 [82–100]
BDG > 80 70 [41–98] 42.5 [27–57] 23.3 [8–38] 85.0 [69–100]
mHLA-DR < 5000 60 [29–90] 57.5 [42–72] 26.1 [8–44] 85.2 [71–98]
Total lymphocytes < 500 80 [55–100] 45 [29–60] 26.7 [10–42] 90.0 [76–100]
CD4+T cells < 200 80 [55–100] 60 [44–75] 33.3 [14–52] 92.3 [82–100]
Association of markers         
 mHLA-DR < 5000 and BDG > 80 40 [9–70] 80 [67–92] 33.3 [6–60] 84.2 [72–95]
 Total lymphocytes < 500 and BDG > 80 70 [41–98] 62.5 [47–77] 31.8 [12–51] 89.3 [77–100]
 CD4+T cells < 200/mm3 and BDG > 80 70 [41–98] 70 [55–84] 36.8 [15–58] 90.3 [79–100]
 Past history of cancer and mHLA-DR < 5000 50 [19–81] 90 [80–99] 55.6 [23–88] 87.8 [77–97]
  1. mHLA-DR: monocyte human leukocyte antigen-DR (AB/c); BDG: β-d-glucan (pg/mL); PPV: positive predictive value; NVP: negative predictive value. Lymphocytes, CD4+ T cell, CD8+ T cell (/mm3)