Monocyte human leukocyte antigen-DR but not β-d-glucan may help early diagnosing invasive Candida infection in critically ill patients

Annals of Intensive Care

Table 3 Predictive value of fungal and immunological markers

	Sensitivity (95% CI)		Specificity (95% CI)		PPV (95% CI)		NPV (95% CI)
Past history of cancer	70	[41–98]	82.5	[70–94]	50.0	[23–76]	91.7	[82–100]
BDG > 80	70	[41–98]	42.5	[27–57]	23.3	[8–38]	85.0	[69–100]
mHLA-DR < 5000	60	[29–90]	57.5	[42–72]	26.1	[8–44]	85.2	[71–98]
Total lymphocytes < 500	80	[55–100]	45	[29–60]	26.7	[10–42]	90.0	[76–100]
CD4+T cells < 200	80	[55–100]	60	[44–75]	33.3	[14–52]	92.3	[82–100]
Association of markers
mHLA-DR < 5000 and BDG > 80	40	[9–70]	80	[67–92]	33.3	[6–60]	84.2	[72–95]
Total lymphocytes < 500 and BDG > 80	70	[41–98]	62.5	[47–77]	31.8	[12–51]	89.3	[77–100]
CD4+T cells < 200/mm³ and BDG > 80	70	[41–98]	70	[55–84]	36.8	[15–58]	90.3	[79–100]
Past history of cancer and mHLA-DR < 5000	50	[19–81]	90	[80–99]	55.6	[23–88]	87.8	[77–97]

mHLA-DR: monocyte human leukocyte antigen-DR (AB/c); BDG: β-d-glucan (pg/mL); PPV: positive predictive value; NVP: negative predictive value. Lymphocytes, CD4+ T cell, CD8+ T cell (/mm³)