Table 1 Respiratory mechanics and gas exchange during ventilation with tidal volumes of 6 and 3 ml/kg PBW

Tidal volume (ml)

400 (378–443)

215 (190–225)

Respiratory rate (min⁻¹)

12 (10–13)

12 (10–14)

0.096

Plateau pressure (cmH₂O)

18 (17–20)

15 (13–17)

0.003

PEEP (cmH₂O)

6 (5–7)

8 (6–8)

0.034

Driving pressure (cmH₂O)

12 (10–14)

7 (6–9)

0.003

Respiratory system compliance (ml/cmH₂O)

35 (29–40)

27 (23–32)

0.013

EELV (ml)

904 (664–1043)

538 (494–827)

0.024

Strain

0.50 (0.43–0.59)

0.38 (0.24–0.50)

0.529

PaO₂ (mmHg)

100 (86–111)

97 (80–120)

0.782

PaCO₂ (mmHg)

36 (32–37)

39 (36–44)

0.074

pH

7.45 (7.43–7.50)

7.40 (7.34–7.45)

0.027

FiO₂

0.40 (0.35–0.50)

0.40 (0.35–0.50)

0.635

F_ECMOO₂

0.65 (0.60–0.80)

0.70 (0.60–0.80)

0.283

ECMO blood flow (l/min)

3.1 (2.9–3.7)

3.3 (2.9–3.5)

0.327

ECMO sweep flow (l/min)

3.0 (2.38–5.00)

5.0 (3.5–6.5)

0.004

Fluid balance (l)

0.736 (-0.19–2.34)

1.725 (508–3.165)

0.377

Urine output (l)

1.57 (0.85–2.88)

1.18 (0.88–2.16)

0.206

Creatinine (mg/dl)

1.12 (0.80–1.41)

1.22 (0.79–2.11)

0.804

Urea (mg/dl)

58 (33.5–77.5)

57 (40.25–79.75)

0.974

Use of RRT (n)

2

2

1

Haemoglobin (g/dl)

9.1 (8.85–10.05)

8.8 (8.47–9.47)

0.083