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Table 2 Comparison between patients with and without a hyperinflammatory subtype (defined as a IL-6 level in bronchoalveolar lavage fluid above 680 pg/ml during ventilation with a tidal volume of 6 ml/kg)

From: Biotrauma during ultra-low tidal volume ventilation and venoarterial extracorporeal membrane oxygenation in cardiogenic shock: a randomized crossover clinical trial

 

Hyperinflamed

Non-hyperinflamed

P

Age

58 (54–63)

62 (47–66)

0.840

Sex

7 male/4 female

5 male/1 female

0.768

SAPS3

58 (53–74)

57 (62–69)

0.725

Days on ECMO

9 (6–15)

8 (7–9)

0.880

Days of mechanical ventilation

14 (8–29)

18 (10–20)

0.960

Mortality

6 (55%)

5 (83%)

0.333

DP (cmH2O) at 6 ml/kg PBW

10 (10–11)

13 (12–14)

0.189

DP (cmH2O) at 3 ml/kg PBW

7 (7–9)

7 (6–9)

1

RR (min−1) at 6 ml/kg PBW

12 (10–13)

12 (11–14)

0.473

RR (min−1) at 3 ml/kg PBW

11 (10–14)

13 (11–14)

0.444

PaO2 (mmHg) at 6 ml/kg PBW

104 (90–117)

92 (75–101)

0.264

PaO2 (mmHg) at 3 ml/kg PBW

105 (83–170)

83 (72–110)

0.350

pH at 6 ml/kg PBW

7.45 (7.43–7.50)

7.45 (7.43–7.48)

0.827

pH at 3 ml/kg PBW

7.40 (7.34–7.45)

7.40 (7.37–7.45)

0.879

HR (min−1) at 6 ml/kg PBW

87 (79–98)

86 (84–88)

0.664

HR (min−1) at 3 ml/kg PBW

88 (76–91)

93 (92–95)

0.664

PCP (mmHg) at 6 ml/kg PBW

14 (12–19)

17 (16–18)

0.694

PCP (mmHg) at 3 ml/kg PBW

18 (12–23)

14 (13–14)

0.793

MAP (mmHg) at 6 ml/kg PBW

76 (71–84)

74 (66–83)

0.828

MAP (mmHg) at 3 ml/kg PBW

74 (68–90)

70 (68–75)

0.545

Fluid balance at 6 ml/kg (l)

1.50 (-0.59–3.60)

0.46 (0.04–1.60)

0.660

Fluid balance at 3 ml/kg (l)

2.08 (0.79–4.34)

1.14 (0.61–1.63)

0.462

  1. Data are expressed as median (interquartile range)
  2. SAPS3: Simplified Acute Physiology Score III, DP: driving pressure, PBW: predicted body weight, RR: respiratory rate, HR: heart rate, MAP: mean systemic arterial pressure