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Table 2 Summary of studies and risk factors

From: Risk factors for invasive aspergillosis in ICU patients with COVID-19: current insights and new key elements

References Patients Included (patients with IA/ total of patients) Respiratory diseases Smoking Cardiovascular disease Hepatic disease Diabetes Chronic Kidney Disease IA: diagnosis from ICU admission (days) Type of respiratory support Steroids Other imunomodulatory therapies Intercurrent infections Previous antimicrobial treatment
Alanio 9/27 2/9 NA 7/9 NA 3/9 NA NA MV 6/9 NA NA NA
Bartoletti 30/108 4/30 NA 19/30 NA 5/30 6/30 4 (2 to 8) MV 18/30 22/30 NA NA
Borman 61 NA NA NA NA NA NA NA MV NA NA NA NA
Dupont 19/106 6/19 NA 8/19 1/19 7/19 2/19 10 (4 to 23) MV, SV 7/19 NA 19/19 NA
Falces-Romero 10 4/10 NA 1/10 NA 5/10 NA NA MV 10/10 4/10 NA NA
Flikweert 7 NA NA NA NA NA NA 19,5 (1 to 24) MV 4/7 NA NA NA
Gangneux 7/45 0/7 1/7 5/7 NA 2/7 1/7 NA MV NA NA NA NA
Helleberg 2/8 1/2 2/2 1/2 NA NA NA 5 and 1 days MV 1/2 0/2 None documented 2/2
Koehler 5/19 2/5 2/5 2/5 1/5 1/5 NA NA MV 3/5 NA NA NA
Lamoth 3/80 2/3 NA 2/3 NA 1/3 NA 7 (3 to 8) MV NA 3/3 NA 3/3
Marr 20 7/20 NA 12/20 1/20 6/20 3/20 9,5 (-1 to 24) MV 4/20 6/20 NA NA
Mitaka 4/7 1/4 NA 1/4 0/4 1/4 1/4 6,8 (1 to 14) MV 4/4 1/4 NA 4/4
Nasir 5/23 NA NA 5/9 NA 8/9 NA 8 MV 5/5 3/5 5/5 5/5
Rothe 2/140 NA NA NA NA NA NA NA MV, SV NA NA Yes (number not specified) 2/2
Rutsaert 7/34 NA NA 3/7 NA 3/7 1/7 8 (5 to 13) MV 1/7 NA NA NA
Van Biesen 9/42 4/9 NA 3/9 NA 1/9 NA 3 (1 to 19) MV 1/9 NA NA NA
Van Arkel 6/31 3/6 NA 1/6 NA NA NA 5 (3 to 14) MV 2/6 0/6 NA NA
Wang 8/104 2/8 2/8 8/8 NA 2/8 2/8 19 MV, SV 6/8 NA NA 6/8
White 25/135 12/25 NA 10/25 1/25 6/25 1/25 NA MV 16/25 NA Yes Yes (number not specified)
Overall              
Studies considering the risk factor/total of studies   14/21 4/21 16/21 5/21 14/21 8/21 12/21   15/21 8/21 3/21 7/21
Patients with the considered risk factor/ total of patients in studies 239 with IA 50/157 7/22 88/173 4/73 51/165 17/120 median 8 days from ICU admission   88/166 39/80 NA NA
  1. BAL broncho-alveolar lavage, EIA enzyme immunoassays, GM galactomannan, GMI galactomannan index, IA invasive aspergillosis, ICU intensive care unit, MV mechanical ventilation, NA not applicable, NC not classifiable, NBL non-directed bronchial lavage, SV spontaneous ventilation