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Table 2 Added predictive value provided by admission CK and myoglobin for AKI prediction

From: Admission serum myoglobin and the development of acute kidney injury after major trauma

 

Model 1

Model 2

Base

Myoglobin

CK

Base

Myoglobin

CK

Estimation of baseline creatinine with MDRD formula

 OR (95% CI)

1.017 (1.003–1.034)

1.007 (0.999–1.042)

1.026 (1.011–1.041)

1.002 (0.999–1.028)

 p-value OR

0.046

0.687

< 0.001

0.866

 AUC (95% CI)

0.897 (0.861–0.931)

0.902 (0.862–0.935)

0.897 (0.860–0.931)

0.798 (0.744–0.847)

0.805 (0.752–0.856)

0.799 (0.745–0.850)

Estimation of baseline creatinine with creatinine on admission

 OR (95% CI)

1.017 (1.003–1.032)

1.019 (0.999–1.043)

1.011 (0.999–1.025)

0.999 (0.998–1.002)

 p-value OR

0.019

0.137

0.15

0.717

 AUC (95% CI)

0.745 (0.691–0.794)

0.759 (0.705–0.808)

0.746 (0.690–0.801)

0.767 (0.714–0.811)

0.769 (0.718–0.815)

0.766 (0.745–0.837)

Estimation of baseline creatinine with lowest creatinine over the first 5 days

 OR (95% CI)

1.050 (1.035–1.065)

1.063 (1.039–1.086)

1.034 (1.019–1.050)

1.033 (1.010–1.056)

 p-value OR

< 0.001

< 0.001

< 0.001

0.006

 AUC (95% CI)

0.654 (0.616–0.694)

0.773 (0.739–0.806)

0.681 (0.642–0.718)

0.782(0.748–0.816)

0.798 (0.764–0.830)

0.787 (0.758–0.822)

  1. Base model 1 is the model established by Haines et al. [21] that includes age, admission phosphate, admission creatinine and hemorrhagic shock as independent variables. Base model 2 is the model established by Harrois et al. [4] that includes maximum prehospital heart rate, minimum systolic blood pressure, admission lactate, injury severity score (ISS) and hemorrhagic shock. Models were constructed for 3 AKI definitions that differ according to baseline creatinine definition. Myoglobin and CK were forced into each model. AUC are given for each model. OR are given per 100 μg/L for myoglobin and per 100 U/L for CK. NRI was calculated only when OR for myoglobin or CK was significantly higher than 1
  2. AUC area under the receiver operating characteristic curve, CK creatine kinase, NRI net reclassification index, OR odds ratio