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Annals of Intensive Care

Table 1 Baseline characteristics of patients (n = 26)

From: High mean arterial pressure target to improve sepsis-associated acute kidney injury in patients with prior hypertension: a feasibility study

Characteristics

All patients

(n = 26)

Group A: from high to low MAP target

(n = 14)

Group B: from low to high MAP target

(n = 12)

P value

Demographic characteristics

Age (year)

69 [61–75]

68 [61–75]

69 [60–75]

0.7

Male

21 (80)

11 (79)

10 (83)

0.8

Weight (kg)

80 [65–94]

80 [65–95]

82 [59–100]

0.8

Body Mass Index

27 [24–32]

28 [24–31]

26 [22–32]

0.8

Reason for admission

   

0.05

 Medical

10 (38)

3 (21)

7 (58)

 

 Surgical

16 (62)

11 (79)

5 (42)

 

Antihypertensive treatment

   

0.4

 Calcic inhibitor

13 (50)

8 (57)

5 (42)

 

 Angiotensin converting enzyme inhibitor

10 (39)

5 (36)

9 (75)

 

 Beta-blockers

11 (42)

5 (36)

6 (50)

 

 Diuretic

2 (8)

1 (7)

1 (8)

 

Comorbidities

   

0.8

 Coronaropathy

7 (27)

4 (29)

3 (25)

 

 Valvular disease

3 (12)

1 (7)

2 (17)

 

 Rhythmic disease

8 (31)

5 (36)

3 (25)

 

 Heart failure

4 (15)

3 (21)

1 (8)

 

 Peripheral arterial disease

1 (4)

1 (7)

0 (0)

 

 Ischemic stroke

1 (4)

1 (7)

0 (0)

 

 Chronic kidney failure

4 (15)

3 (21)

1 (8)

 

 Respiratory disease

8 (31)

4 (29)

4 (33)

 

 Diabetes mellitus

10 (39)

6 (43)

4 (33)

 

 Neoplastic disease

10 (39)

7 (50)

3 (25)

 

 Smoking

7 (27)

4 (29)

3 (25)

 

Prior kidney function

   

 Baseline sCr (µmol/L)

71 [53–90]

68 [41–90]

73 [60–90]

0.6

 Baseline eGFRa (mL/min/1.73 m2)

92 [75–104]

92 [74–114]

89 [76–97]

0.6

Characteristics at inclusion

   

 SOFA score

9 [7–13]

9 [6–10]

9 [7–14]

0.5

 SAPS II score

52 [36–62]

48 [34–53]

61 [41–73]

0.04

 Time from initiation of norepinephrine to inclusion (hours)

18 [12–24]

18 [16–24]

16 [10–23]

0.3

Baseline KDIGO stage

   

0.6

 1

9 (35)

4 (29)

5 (42)

 

 2

13 (50)

7 (50)

6 (50)

 

 3

4 (15)

3 (21)

1 (8)

 

sCr (µmol/L)

124 [75–192]

143 [116–206]

105 [69–155]

0.1

MAP (mmHg)

71 [65–72]

71 [69–73]

67 [65–73

0.2

  1. Data are expressed as the median [interquartile range] or number (%)
  2. aCalculated using the CKD-EPI formula
  3. bCalculated using the UV/P formula
  4. ARB: angiotensin II receptor blocker; sCr: serum creatinine; SOFA: Sepsis-related Organ Failure Assessment; SAPS II: simplified acute physiology score II; eGFR: estimated glomerular filtration rate; MAP: mean arterial pressure; ICU: intensive care unit
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