Impact of ICU transfers on the mortality rate of patients with COVID-19: insights from comprehensive national database in France

Sanchez, Marc-Antoine; Vuagnat, Albert; Grimaud, Olivier; Leray, Emmanuelle; Philippe, Jean-Marc; Lescure, François-Xavier; Boutonnet, Mathieu; Coignard, Hélène; Hibon, Agnès Ricard; Sanchez, Stephane; Pottecher, Julien

doi:10.1186/s13613-021-00933-2

Annals of Intensive Care

Table 2 Univariate and multivariate mortality models of patients with COVID-19 hospitalized at the intensive care unit (ICU) in France from 1 March to 21 June 2020

From: Impact of ICU transfers on the mortality rate of patients with COVID-19: insights from comprehensive national database in France

	Unadjusted model			Model with no population restriction			Model restricted on transferred patients and if not transferred still in ICU at Day 5
	Unadjusted risk ratio	95% CI	P-value	Adjusted risk ratio	95% CI	P-value	Adjusted risk ratio	95% CI	P-value
Age
≤ 29 years	1			1			1
30–39 years	2.579	1.552–4.286	0.0003	2.450	1.541–3.896	0.0002	2.018	1.164–3.501	0.0124
40–49 years	2.739	1.702–4.408	< 0.0001	2.583	1.684–3.962	< 0.0001	1.873	1.142–3.075	0.0130
50–59 years	4.760	3.014–7.516	< 0.0001	4.466	2.961–6.736	< 0.0001	3.299	2.044–5.322	< 0.0001
60–69 years	7.374	4.688–11.598	< 0.0001	7.069	4.710–10.61	< 0.0001	5.057	3.152–8.112	< 0.0001
70–79 years	10.176	6.473–15.994	< 0.0001	9.889	6.593–14.832	< 0.0001	6.883	4.292–11.039	< 0.0001
≥ 80 years	12.837	8.148–20.225	< 0.0001	13.481	8.970–20.261	< 0.0001	8.966	5.574–14.42	< 0.0001
Sex (male)	1.105	1.036–1.177	0.0022	1.129	1.069–1.193	< 0.0001	1.177	1.103–1.255	< 0.0001
Hospitalization time period
Up to 23 March 2020	1			1			1
23–29 March 2020	0.813	0.751–0.879	< 0.0001	0.888	0.829–0.950	0.0006	0.842	0.780–0.910	< 0.0001
30 March to 05 April 2020	0.753	0.690–0.823	< 0.0001	0.818	0.763–0.878	< 0.0001	0.787	0.726–0.853	< 0.0001
06–19 April 2020	0.772	0.706–0.844	< 0.0001	0.765	0.712–0.822	< 0.0001	0.789	0.722–0.861	< 0.0001
20 April 2020 to 21 June 2020	0.610	0.549–0.678	< 0.0001	0.607	0.549–0.672	< 0.0001	0.580	0.514–0.655	< 0.0001
Region with high incidence
GE, IDF, HDF, BFC vs others*	1.329	1.245–1.419	< 0.0001	1.504	1.418–1.595	< 0.0001	1.547	1.441–1.659	< 0.0001
Hospital type
University teaching hospital	1			1			1
Public hospital	1.038	0.973–1.106	0.2572	0.979	0.926–1.035	0.4614	0.940	1.003–0.881	0.0597
Private hospital	0.943	0.867–1.025	0.1670	0.825	0.767–0.887	< 0.0001	0.774	0.844–0.710	< 0.0001
Location before ICU admission (hospital vs home)	0.973	0.916–1.033	0.3661	0.954	0.906–1.005	0.0760	0.942	0.999–0.888	0.0468
ICU transfer
Less than 10 km	0.922	0.787–1.080	0.3144	0.984	0.854–1.133	0.8221	1.005	0.870–1.159	0.9512
10–50 km	0.784	0.664–0.925	0.0039	0.791	0.679–0.922	0.0028	0.819	0.702–0.956	0.0114
50–200 km	0.846	0.695–1.029	0.0944	0.763	0.624–0.934	0.0088	0.788	0.642–0.967	0.0228
200 km and more	0.431	0.331–0.561	< 0.0001	0.382	0.291–0.500	< 0.0001	0.392	0.298–0.514	< 0.0001

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