Fig. 2
From: Long-term cardiovascular complications following sepsis: is senescence the missing link?
Difference between senescence and apoptosis. Intermediate stress can lead to senescence via p53 and p16 pathway, resulting in persisting cell dysfunction. High cellular stress can induce apoptosis through upregulation of p53, resulting to cell death and elimination. High level of p53 contributes to the induction of BH3-only proteins (BIM, PUMA, NOXA) that inhibits pro-survival BCL-2 family members (BCL-XL, MCL-1, BCL 2)