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Annals of Intensive Care

Table 4 Comparison of patient’s characteristics according to their obese status in univariate analysis

From: Impact of obesity on survival in COVID-19 ARDS patients receiving ECMO: results from an ambispective observational cohort

 

Non-obese patients (n = 44)

Obese patients (n = 29)

p value

Demographic characteristics

 Age (years)

60.5 (56–64.5)

61 (54–64)

0.78

 Sex (male)

35 (79.5%)

21 (72.4%)

0.48

 BMI (kg/m2)

26.45 (25.35–27.8)

33.5 (31–35.8)

< 0.001

First wave, n (%)

16 (36)

7(24)

0.27

Severity scores

 SAPS II

30 (25.5–36)

29 (25.5–34.5)

0.60

 SOFA

3 (2–4)

3 (2–4)

0.95

Charlson score

2 (2–3)

2 (1–3)

0.58

ICU therapy before ECMO

 High-flow nasal O2, n (%)

38 (86)

26 (90)

0.68

  Duration (days)

5 (1–7)

2 (1–6)

0.08

 Non-invasive ventilation, n (%)

18 (41)

17 (59)

0.14

  Duration (days)

4 (0–6)

1 (0.5–3)

0.15

 Prone positioning, n (%)

44 (100)

28 (97)

0.21

  Number of sessions

2 (1–5)

2 (1.5–4)

0.88

 Dexamethasonea, n (%)

28 (65)

19 (65.5)

0.97

Time from first symptoms to intubation, days

11 (7.5–15)

10 (7–13)

0.1

Time from hospitalization to intubation, days

5.5 (1–9)

4 (1–6)

0.06

Time from ICU admission to intubation, days

4 (1–7)

2 (0–4)

0.048

Predictive survival scores under ECMO

 RESP score

1 (0–2)

1 (1–4)

0.09

 ECMO net score

5.5 (4–6)

4.5 (4–6)

0.73

 PRESERVE score

4 (3–5)

2 (1–3)

< 0.001

 SOFA before ECMO

8 (4–9)

5 (4–8)

0.58

MV duration before ECMO, days

7 (3–10.5)

5 (3–8)

0.35

Time from ICU admission to ECMO, days

11 (8–14.5)

9 (4–11)

0.02

Ventilation parameters before ECMO

 FiO2

100

100

0.58

 Plateau pressure, cmH2O

28 (25–30)

29 (25–31)

0.92

 Positive end-expiratory pressure, cmH2O

10 (8–12)

14 (10–15)

< 0.001

 Driving pressure

17 (14–20)

14.5 (12–20)

0.1

 Tidal volume, mL/kg predicted bodyweight

5.7 (5–6,21)

5.85 (5.6–6.2)

0.30

 Respiratory rate, breath per minute

26 (23–30)

26.5 (20–30)

0.83

 Mechanical power, J/min

17.7 (14.07–22.22)

20.3 (17.7–29.7)

0.06

 Ventilatory ratio

2.42 (1.55–2.90)

2.34 (1.87–2.75)

0.81

 Static compliance, mL/cmH2O

23 (15.5–27.33)

26.25 (21–39.09)

0.07

Last blood-gas values before ECMO

 PaO2/FiO2 ratio

71.5 (64–84)

75 (62–81)

0.93

 pH

7.35 (7.26–7.38)

7.31 (7.26–7.39)

0.49

 PaCO2, mmHg

57.5 (50.5–65.5)

60 (52–66)

0.99

  1. 73 patients were included in this analysis, 3 patients were excluded because of missing data for BMI
  2. Data are expressed as median (interquartiles) or number (percentage, %)
  3. Obesity was defined by a BMI superior or equal to 30 g/m2
  4. Mechanical power (MP) was calculated as follows: MP = 0.098 × tidal volume × respiratory rate × (peak pressure − ½ × driving pressure). Driving pressure was defined as plateau pressure minus positive end-expiratory pressure. Static compliance was defined as tidal volume divided by driving pressure
  5. BMI: body mass index; NSAID: non-steroidal anti-inflammatory drug; ACE: angiotensin converting enzyme; ARB: angiotensin II receptor blockers; SAPS II: Simplified Acute Physiology score; SOFA: Sequential Organ Function; ICU: intensive care unit; ECMO: extra-corporeal membrane oxygenation; MV: mechanical ventilation; O2: oxygen; PaO2: partial pressure of arterial oxygen; FiO2: fraction of Inspired oxygen; PaCO2: partial pressure of arterial carbon dioxide; PaO2/FiO2: ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen; RESP score [17]: Respiratory Extracorporeal Membrane Oxygenation Survival Prediction Score; ECMO net score [18]: score from the Italian ECMO network; PRESERVE score [19]: PRedicting dEath for SEvere ARDS on VV-ECMO score
  6. aPatients receiving dexamethasone 6 mg per day or equivalent dose of corticosteroids
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