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Table 5 Univariable and multivariate analyses of factors associated with a non-immune cause in the subgroup of patients with ARF complicating a known Svv (n = 70)a

From: Causes of acute respiratory failure in patients with small-vessel vasculitis admitted to intensive care units: a multicenter retrospective study

 

Immune ARF (n  = 14)

Non-immune ARF (n  = 56)

Univariable analysis

p

Multivariate analysis

p

OR [95% CI]

OR [95%CI]

Immunosuppression

7 (50)

50 (89)

8.33 [2.17–32.05]

0.002

9.41 [1.52–58.3]

0.016

Severe chronic renal failure, n (%)

3 (21)

25 (45)

2.95 [0.74–11.76]

0.124

NR

0.33

Time from Svv diagnosis to ICU admission, months

21 [8–60]

56 [9.5–132]

1.009 [0.999–1.020]b

0.084

NR

0.099

BVAS (Birmingham Vasculitis Activity Score)

17.5 [8–21]

0 [0–6]

0.85 [0.78–0.92]b

< 0.0001

0.84 [0.77–0.93]

< 0.0001

Time from resp. symptoms to ICU admission,  < 3 days

4 (29)

31 (55)

3.10 [0.87–11.07]

0.082

NR

0.13

  1. NR not retained in the model at the p  =  0.05 significance level
  2. aIncluding the second admission only in the 9 patients with 2 ICU admissions
  3. bPer unit (per month since the diagnosis of ARF or per BVAS point)