From: Insights from patients screened but not randomised in the HYPERION trial
Characteristics | TTM | ICU survival | Good neurological outcome at ICU dischargea | Good neurological outcome on day 90a |
---|---|---|---|---|
No-flow > 10 min (n = 234) | 76/234 (32.5%) | 10/234 (4.3%) | 5/233 (2.1%) | 5/233 (2.1%) |
Low-flow > 60 min (n = 35) | 7/35 (20.0%) | 2/35 (5.7%) | 1/35 (2.8%) | 1/35 (2.8%) |
Haemodynamic instability (defined as norepinephrine > 1 µg/kg/min) (n = 120) | 23/120 (19.2%) | 21/120 (17.5%) | 16/120 (13.3%) | 16/120 (13%) |
Time from cardiac arrest to screening > 300 min (n = 141) | 26/140 (18.6%) | 48/141 (34.0%) | 33/140 (23.6%) | 32/140 (22.8%) |
Moribund (n = 291) | 76/291 (26.1%) | 10/289 (3.4%) | 9/289 (3.1%) | 9/289 (3.1%) |
Cirrhosis Child–Pugh C (n = 7) | 3/7 (42.8%) | 2/7 (28.6%) | 1/6 (16.6%) | 1/6 (16.6%) |
Pregnant or breastfeeding (n = 1) | 0/1 (0%) | 0/1 (0%) | 0/1 (0%) | 0/1 (0%) |
Inclusion in another study (n = 3) | 2/3 (66.6%) | 1/3 (33.3%) | 0/2 (0%) | 0/2 (0%) |
High risk of bleeding (n = 5) | 2/5 (40.0%) | 1/5 (20.0%) | 1/5 (20%) | 1/5 (20%) |
Logistical reasonb (n = 307) | 126/305 (41.3%) | 112/307 (36.5%) | 97/303 (32.0%) | 93/299 (31.1%) |