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Table 1 Multivariate linear regression analysis output for variables independently associated with IgA, IgG and IgM on day 1

From: Higher levels of IgA and IgG at sepsis onset are associated with higher mortality: results from the Albumin Italian Outcome Sepsis (ALBIOS) trial

Variable

B

95% CI

p

IgA

 Female sex

− 34.1

− 47.5: − 20.7

7.0 × 10–7

 BMI

2.6

1.4: 3.8

1.5 × 10–5

 White blood cell count at baseline

1.4

0.7: 2.1

6.0 × 10–5

 CV comorbidities

28.6

11.2: 46.1

0.001

 Randomized to crystalloids

19.4

6.3: 32.5

0.004

 Onco-haematologic disease

− 48.0

− 87.0: − 9.1

0.016

 Creatinine

− 3.5

− 7.6: 0.6

0.090

 Immunocompromised state

− 18.3

− 40.0: 3.3

0.097

IgG

 Female sex

− 88.5

− 135.5: − 41.4

2.4 × 10–4

 White blood cell count at baseline

4.2

1.7: 6.6

0.001

 Randomized to crystalloids

73.7

27.5: 120.0

0.002

 BMI

5.8

1.7: 10.0

0.006

 Shock

− 55.1

− 101.8: − 8.4

0.021

 Liver disease

188.5

− 3.5: 380.4

0.054

 Heart rate

− 0.9

− 2.0: 0.3

0.127

 Immunocompromised state

− 9.3

− 79.1: 60.6

0.794

IgM

 Age

− 0.6

− 0.9: − 0.2

0.002

 Shock

− 14.4

− 25.3: − 3.6

0.009

 Onco-haematologic disease

− 30.1

− 58.2: − 2.0

0.036

 White blood cell count at baseline

0.4

− 0.1: 1.0

0.127

 Mean arterial pressure

0.2

− 0.2: 0.5

0.329

  1. Output for multivariable linear regression analysis with continuous Ig concentration as dependent variable
  2. Included in the regression analyses are the variables which were significant in Additional file 1: Tables S1, S2 and S3. For IgG, AIDS was not included due to confounding by immuno-compromised state. Location of infection was not included in this analysis