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Table 2 Cox regression analysis for 28- and 90-day survival

From: Higher levels of IgA and IgG at sepsis onset are associated with higher mortality: results from the Albumin Italian Outcome Sepsis (ALBIOS) trial

Ig

Outcome

Model

HR

95% CI

P

IgA

28-day mortality

(> 150 mg/dL)

Univariate

1.24

1.07–1.43

0.004

Multivariate

1.50

1.18–1.92

0.001

90-day mortality

(> 150 mg/dL)

Univariate

1.24

1.09–1.41

0.001

Multivariate

1.54

1.25–1.91

6.3 × 10–5

IgG

28-day mortality

(> 750 mg/dL)

Univariate

1.21

1.02–1.44

0.033

Multivariate

1.83

1.33–2.51

1.8 × 10–4

90-day mortality

(> 750 mg/dL)

Univariate

1.16

0.99–1.37

0.070

Multivariate

1.66

1.23–2.25

0.001

  1. Based upon the restricted cubic spline for IgA > 150 was included (N = 124) and for IgG > 750 (N = 294)
  2. All values were Z-standardized—HR for 1 SD
  3. Both multivariate Cox proportional hazards regression analyses were adjusted for clinical characteristics which were associated with 28- and 90-day mortality with a p value of < 0.0001: age, shock, baseline SOFA score, creatinine, platelets, cardiovascular comorbidities, renal comorbidities and COPD, see Additional file 1: Table S5