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Annals of Intensive Care

Table 2 Sensitivity analysis comparing SC vs. subgroups of EC for the 30-day neurological favourable outcome

From: Impact of cooling method on the outcome of initial shockable or non-shockable out of hospital cardiac arrest patients receiving target temperature management: a nationwide multicentre cohort study

 

All patients

Cooling method

Crude analysis

Multivariable analysis

Propensity score analysis

P value

SC

EC

OR (95% CI)

AOR (95% CI)a

OR (95% CI)b

SC vs. EC as endovascular device and excluding dialysis cooling

 Overall

378/1060 (35.7)

330/946 (34.9)

48/114 (42.1)

1.36 (0.91–2.02)

2.17 (1.31–3.60)

1.75 (1.18–2.59)

0.005

 Shockable

304/504 (60.3)

270/452 (59.7)

34/52 (65.4)

1.27 (0.70–2.32)

1.89 (0.87–4.10)

1.75 (0.93–3.29)

0.081

 Non-shockable

74/556 (13.3)

60/494 (12.1)

14/62 (22.6)

2.11 (1.10–4.06)

2.91 (1.43–5.91)

2.31 (1.20–4.43)

0.012

SC vs. EC after excluding patients treated with both SC and EC method

 Overall

369/1055 (35.0)

322/931 (34.6)

47/124 (37.9)

1.15 (0.78–1.70)

1.56 (0.87–2.80)

1.30 (0.88–1.91)

0.184

 Shockable

296/495 (59.8)

264/441 (59.9)

32/54 (59.3)

0.98 (0.55–1.73)

1.45 (0.63–3.33)

1.34 (0.75–2.42)

0.325

 Non-shockable

73/560 (13.0)

58/490 (11.8)

15/70 (21.4)

2.03 (1.08–3.83)

2.25 (1.18–4.32)

2.19 (1.17–4.12)

0.014

  1. Values are expressed numbers (percentages) unless indicated otherwise
  2. TTM target temperature management, SC surface cooling, EC endovascular cooling, OR odds ratio, AOR adjusted odds ratio, CI confidence interval
  3. aShown is the adjusted odds ratio from the multivariable random effects logistic regression analysis with hospital treated as a random effect, with stratification according to age, sex, cause of arrest, bystander witness, bystander CPR status, use of public-access AEDs, prehospital adrenaline administration, prehospital advanced airway management, EMS response time, target temperature, TTM induction time
  4. bShown is the odds ratio from the univariable logistic regression analysis with inverse probability weighting according to the propensity score
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