Table 1 Predictive factors of publication in high-impact general journals in the derivation cohort, compared to high-impact critical care journals

Sample size

 < 46

107 (21%)

1

1

46–120

141 (27%)

3.58

0.76–16.92

3.00

0.57–15.68

121–352

137 (27%)

15.35

3.58–65.77

8.56

1.72–42.68

 > 352

125 (25%)

120.17

28.19–512.23

61.09

11.51–324.22

Number of centers

1

258 (50%)

1

1

2–10

117 (23%)

4.74

2.55–8.79

1.84

0.84–4.02

 > 10

135 (27%)

17.21

9.65–30.70

3.28

1.43–7.54

International trial

Yes / No

76 (15%) / 434 (85%)

4.93

2.96–8.20

1.76

0.84–3.66

Primary endpoint

Mortality alone

93 (18%)

8.66

2.26–14.24

3.87

1.92–7.79

Composite including mortality

16 (3%)

9.11

3.20–25.98

12.91

3.14–53.01

Other

401 (79%)

1

1

Interpretation result

Significant for benefit

233 (46%)

0.42

0.27–0.64

1.28

0.70–2.35

Significant for harm

6 (1%)

1.04

0.19–5.79

0.38

0.04–3.40

Unsignificant

271 (53%)

1

1

Type of intervention

Drug (Yes/No)

213 (42%) / 297 (58%)

0.71

0.48–1.06

0.80

0.43–1.49

Country of first author

USA (Yes/No)

111 (22%) / 399 (78%)

1.34

0.84–2.13

1.31

0.69–2.48

Topic

Sepsis

84 (17%)

1

1

Cardiovascular

89 (18%)

1.62

0.81–3.28

1.26

0.47–3.43

Ventilation

130 (25%)

1.29

0.66–2.50

6.27

2.30–17.11

Miscellaneous

207 (40%)

1.39

0.75–2.58

5.10

2.02–12.89