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Table 4 Multiple logistic regression analysis of in-hospital mortality risk among coronavirus disease 2019 patients on mechanical ventilation after adjusting for within-hospital clustering

From: Association between mortality and age among mechanically ventilated COVID-19 patients: a Japanese nationwide COVID-19 database study

Variable

After multiple imputation

Odds ratio

95%CI

p-value

Age ≥ 90

92.63

16.66–514.98

 < 0.01

 80–89

13.17

7.21–24.06

 < 0.01

 70–79

6.92

4.23–11.31

 < 0.01

 60–69

2.60

1.65–4.08

 < 0.01

 59 ≤ (reference)

1

  

Male

1.04

0.74–1.46

0.82

Body mass index ≥ 30 kg/m2

1.37

0.91–2.07

0.14

Smoking history

1.16

0.80–1.68

0.44

Comorbidity

1.33

0.87–2.03

0.19

 Immunosuppression

2.17

1.14–4.12

0.02

Admission date

  3rd wave

0.86

0.59–1.26

0.45

 2nd wave

0.62

0.41–0.95

0.03

 1st wave (reference)

1

  

Vital signs on admission

   

 Fever (≥ 38 °C)

0.83

0.61–1.13

0.25

 SpO2 < 90%

1.00

0.68–1.46

0.99

 Respiratory rate ≥ 30

1.02

0.70–1.50

0.90

 Systolic blood pressure ≤ 80 mmHg

0.25

0.07–0.96

0.04

ARDS

  Severe

6.73

4.50–10.04

 < 0.01

 Moderate

0.63

0.39–1.02

0.06

 Mild

0.54

0.23–1.28

0.16

 None (reference)

1

  

Drug administration for COVID-19

0.97

0.56–1.67

0.90

Steroid use

1.26

0.84–1.88

0.26

Drug administration for coagulopathy

0.96

0.68–1.35

0.82

Days from symptom onset to IMV

1.00

1.00–1.01

0.47

  1. Analysis based on records from the COVID-19 Registry Japan
  2. ARDS acute respiratory distress syndrome, IMV invasive mechanical ventilation